HCA2 receptor (hcar2_human)
FAMILY
Class A (Rhodopsin) Alicarboxylic acid receptors Hydroxycarboxylic acid receptors HCA2 receptor
GENE
HCAR2
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptor
SOURCE
SWISSPROT
SEQUENCE
| N-term | |||||||||
|
M
|
N
|
R
|
H
|
H
|
L
|
Q
|
D
|
H
|
F
|
| 10 | |||||||||
|
L
|
E
|
I
|
D
|
K
|
K
|
N
|
C
|
C
|
V
|
| 20 | |||||||||
| TM1 | |||||||||
|
F
|
R
|
D
|
D
|
F
|
I
|
V
|
K
|
V
|
L
|
| 30 | |||||||||
|
P
|
P
|
V
|
L
|
G
|
L
|
E
|
F
|
I
|
F
|
| 40 | |||||||||
|
G
|
L
|
L
|
G
|
N
|
G
|
L
|
A
|
L
|
W
|
| 50 | |||||||||
| ICL1 | |||||||||
|
I
|
F
|
C
|
F
|
H
|
L
|
K
|
S
|
W
|
K
|
| 60 | |||||||||
| TM2 | |||||||||
|
S
|
S
|
R
|
I
|
F
|
L
|
F
|
N
|
L
|
A
|
| 70 | |||||||||
|
V
|
A
|
D
|
F
|
L
|
L
|
I
|
I
|
C
|
L
|
| 80 | |||||||||
|
P
|
F
|
L
|
M
|
D
|
N
|
Y
|
V
|
R
|
R
|
| 90 | |||||||||
| ECL1 | TM3 | ||||||||
|
W
|
D
|
W
|
K
|
F
|
G
|
D
|
I
|
P
|
C
|
| 100 | |||||||||
|
R
|
L
|
M
|
L
|
F
|
M
|
L
|
A
|
M
|
N
|
| 110 | |||||||||
|
R
|
Q
|
G
|
S
|
I
|
I
|
F
|
L
|
T
|
V
|
| 120 | |||||||||
|
V
|
A
|
V
|
D
|
R
|
Y
|
F
|
R
|
V
|
V
|
| 130 | |||||||||
| ICL2 | |||||||||
|
H
|
P
|
H
|
H
|
A
|
L
|
N
|
K
|
I
|
S
|
| 140 | |||||||||
| TM4 | |||||||||
|
N
|
R
|
T
|
A
|
A
|
I
|
I
|
S
|
C
|
L
|
| 150 | |||||||||
|
L
|
W
|
G
|
I
|
T
|
I
|
G
|
L
|
T
|
V
|
| 160 | |||||||||
| ECL2 | |||||||||
|
H
|
L
|
L
|
K
|
K
|
K
|
M
|
P
|
I
|
Q
|
| 170 | |||||||||
|
N
|
G
|
G
|
A
|
N
|
L
|
C
|
S
|
S
|
F
|
| 180 | |||||||||
| TM5 | |||||||||
|
S
|
I
|
C
|
H
|
T
|
F
|
Q
|
W
|
H
|
E
|
| 190 | |||||||||
|
A
|
M
|
F
|
L
|
L
|
E
|
F
|
F
|
L
|
P
|
| 200 | |||||||||
|
L
|
G
|
I
|
I
|
L
|
F
|
C
|
S
|
A
|
R
|
| 210 | |||||||||
|
I
|
I
|
W
|
S
|
L
|
R
|
Q
|
R
|
Q
|
M
|
| 220 | |||||||||
| ICL3 | TM6 | ||||||||
|
D
|
R
|
H
|
A
|
K
|
I
|
K
|
R
|
A
|
I
|
| 230 | |||||||||
|
T
|
F
|
I
|
M
|
V
|
V
|
A
|
I
|
V
|
F
|
| 240 | |||||||||
|
V
|
I
|
C
|
F
|
L
|
P
|
S
|
V
|
V
|
V
|
| 250 | |||||||||
|
R
|
I
|
R
|
I
|
F
|
W
|
L
|
L
|
H
|
T
|
| 260 | |||||||||
| ECL3 | |||||||||
|
S
|
G
|
T
|
Q
|
N
|
C
|
E
|
V
|
Y
|
R
|
| 270 | |||||||||
| TM7 | |||||||||
|
S
|
V
|
D
|
L
|
A
|
F
|
F
|
I
|
T
|
L
|
| 280 | |||||||||
|
S
|
F
|
T
|
Y
|
M
|
N
|
S
|
M
|
L
|
D
|
| 290 | |||||||||
| H8 | |||||||||
|
P
|
V
|
V
|
Y
|
Y
|
F
|
S
|
S
|
P
|
S
|
| 300 | |||||||||
|
F
|
P
|
N
|
F
|
F
|
S
|
T
|
L
|
I
|
N
|
| 310 | |||||||||
| C-term | |||||||||
|
R
|
C
|
L
|
Q
|
R
|
K
|
M
|
T
|
G
|
E
|
| 320 | |||||||||
|
P
|
D
|
N
|
N
|
R
|
S
|
T
|
S
|
V
|
E
|
| 330 | |||||||||
|
L
|
T
|
G
|
D
|
P
|
N
|
K
|
T
|
R
|
G
|
| 340 | |||||||||
|
A
|
P
|
E
|
A
|
L
|
M
|
A
|
N
|
S
|
G
|
| 350 | |||||||||
|
E
|
P
|
W
|
S
|
P
|
S
|
Y
|
L
|
G
|
P
|
| 360 | |||||||||
|
T
|
S
|
P
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
, 'snake_hcar2_human.png',
{scale: 3});){kind=link}
, 'snake_hcar2_human.jpg',
{scale: 3});){kind=link}
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
, 'helixbox_hcar2_human.png',
{scale: 3});){kind=link}
, 'helixbox_hcar2_human.jpg',
{scale: 3});){kind=link}
MUTATIONS
PHYSIOLOGICAL LIGANDS
butyric acid, β-D-hydroxybutyric acid
STRUCTURE MODELS
STRUCTURES
Found 40 structure(s) - view all details on the Structures page
PDBs: 9IQT, 7XK2, 8H2G, 8I7V, 8I7W, 8IHF, 8IHB, 8IHH, 8IHI, 8IJ3, 8IJA, 8IJB, 8IJD, 8IY9, 8IYH, 8IYW, 8J6I, 8J6J, 8J6L, 8J6P, 8J6Q, 8J6R, 8JER, 8JHN, 8JHY, 8JII, 8JIL, 8JIM, 8K5B, 8K5C, 8JZ7, 8K5D, 8UTD, 9IZA, 9IZC, 9JKY, 9KT7, 9KT8, 7ZL9, 7ZLY