P2Y14 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

June 10, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

UDP, UDP-galactose, UDP-glucose, UDP N-acetyl-glucosamine, UDP-glucuronic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic H8 Q 300 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 K 122 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 122 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 123 3x54 G.H5 C 351 G.H5.23
Van-der-waals H8 Q 300 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 K 212 5x64 G.H5 I 344 G.H5.16
Aromatic TM6 K 230 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 230 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 230 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 123 3x54 G.H5 I 344 G.H5.16
Polar ICL3 H 217 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 217 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 217 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 S 216 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 216 5x68 G.H5 D 341 G.H5.13
Ionic ICL3 K 219 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 219 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 219 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 219 - G.h4s6 E 318 G.h4s6.12
Ionic TM6 R 222 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 222 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 222 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 222 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 I 235 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM7 L 298 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 298 7x56 G.H5 G 352 G.H5.24
Polar TM6 N 223 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 N 223 6x26 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 N 223 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL3 K 219 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 123 3x54 G.H5 L 348 G.H5.20
Polar ICL3 K 219 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 K 219 - G.S6 I 319 G.S6.01
Hydrophobic TM6 N 223 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 223 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 S 231 6x34 G.H5 L 348 G.H5.20
Polar TM6 N 234 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 234 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 222 6x25 G.h4s6 K 314 G.h4s6.08
Polar TM6 N 223 6x26 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 N 223 6x26 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 N 223 6x26 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 V 227 6x30 G.H5 L 348 G.H5.20
Polar TM6 S 221 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 221 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 221 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 F 56 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 F 56 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 119 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 227 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 S 216 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 213 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 227 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM5 I 209 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 N 347 G.H5.19