PTH1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

SPT - Agonist

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36) (Human), PTHrP (Human), TIP39 (Human), PTH (Human), PTH (Mouse), PTH (Rat)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM2 H 223 2x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 314 - G.S1 H 41 G.S1.02
Hydrophobic TM6 K 405 6x37 G.H5 L 394 G.H5.26
Aromatic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 219 2x46 G.H5 Y 391 G.H5.23
Polar TM6 K 405 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 405 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 405 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 314 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 385 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 385 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 306 3x54 G.H5 Y 391 G.H5.23
Polar TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 388 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM6 V 412 6x44 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 314 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 314 - G.S3 V 217 G.S3.01
Polar TM6 K 408 6x40 G.H5 E 392 G.H5.24
Polar TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 313 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 313 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 310 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 388 G.H5.20
Polar TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 388 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 388 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 385 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 388 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 389 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 389 5x65 G.H5 L 394 G.H5.26