D3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CMU

RESOLUTION

3.0 Å

REFERENCE

10.1016/J.MOLCEL.2021.01.003

PUBLICATION DATE

March 10, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

pramipexole - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 135 - G.H5 I 343 G.H5.15
Polar TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 A 131 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 131 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 132 3x54 G.H5 L 348 G.H5.20
Polar TM4 Q 144 4x36 G.HN E 28 G.HN.52
Hydrophobic TM4 Q 144 4x36 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 144 4x36 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 135 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 135 - G.H5 I 344 G.H5.16
Polar TM6 R 323 6x29 G.h4s6 T 316 G.h4s6.10
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 327 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 327 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 136 - G.H5 I 343 G.H5.15
Hydrophobic TM6 E 324 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 324 6x30 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 138 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 136 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 H 137 - G.hns1 R 32 G.hns1.03
Polar ICL2 Q 139 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 139 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Q 139 - G.H5 N 347 G.H5.19
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Polar ICL2 H 140 - G.H5 D 350 G.H5.22
Polar TM5 R 222 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 A 327 6x33 G.H5 L 353 G.H5.25
Aromatic TM6 R 323 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 323 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 323 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Q 139 - G.H5 I 343 G.H5.15
Hydrophobic TM5 R 222 5x72 G.S6 Y 320 G.S6.02
Polar ICL2 P 135 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 135 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 135 - G.H5 N 347 G.H5.19
Polar ICL2 Y 138 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 138 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 138 - G.H5 C 351 G.H5.23
Polar TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 222 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 222 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 222 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 V 331 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 331 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 323 6x29 G.H5 K 349 G.H5.21