B2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F2O

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41594-021-00645-Y

PUBLICATION DATE

Oct. 13, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

61 interactions (Click to see)

LIGANDS

bradykinin - Agonist pubchem gtoplig chembl_ligand drugbank gtoplig

PHYSIOLOGICAL LIGANDS

[des-Arg9]bradykinin, kallidin, Lys-[Hyp3]-bradykinin, [des-Arg10]kallidin, T-kinin, [Hyp3]bradykinin, bradykinin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 264 6x29 G.H5 V 361 G.H5.26
Van-der-waals TM6 T 264 6x29 G.H5 V 361 G.H5.26
Hydrophobic TM2 Y 95 2x42 G.H5 Y 358 G.H5.23
Van-der-waals TM2 Y 95 2x42 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 M 163 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 M 163 - G.S1 L 34 G.S1.02
Polar TM3 D 154 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 154 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 154 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 N 354 G.H5.19
Hydrophobic H8 R 338 8x49 G.H5 E 357 G.H5.22
Van-der-waals H8 R 338 8x49 G.H5 E 357 G.H5.22
Hydrophobic TM2 A 92 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM3 L 159 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM6 V 272 6x37 G.H5 L 360 G.H5.25
Polar ICL2 G 166 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 G 166 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 166 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 267 6x32 G.H5 V 361 G.H5.26
Van-der-waals TM6 R 267 6x32 G.H5 V 361 G.H5.26
Hydrophobic TM5 V 250 5x64 G.H5 L 351 G.H5.16
Hydrophobic ICL2 M 163 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 M 163 - G.H5 F 343 G.H5.08
Polar H8 K 337 8x48 G.H5 V 361 G.H5.26
Hydrophobic H8 K 337 8x48 G.H5 V 361 G.H5.26
Van-der-waals H8 K 337 8x48 G.H5 V 361 G.H5.26
Van-der-waals TM7 V 335 7x56 G.H5 N 359 G.H5.24
Polar H8 G 336 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 G 336 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 G 336 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 G 336 8x47 G.H5 V 361 G.H5.26
Van-der-waals H8 G 336 8x47 G.H5 V 361 G.H5.26
Polar TM3 V 151 3x46 G.H5 Y 358 G.H5.23
Hydrophobic TM3 V 151 3x46 G.H5 Y 358 G.H5.23
Polar TM7 Y 332 7x53 G.H5 N 359 G.H5.24
Hydrophobic TM7 Y 332 7x53 G.H5 N 359 G.H5.24
Van-der-waals TM7 Y 332 7x53 G.H5 N 359 G.H5.24
Hydrophobic TM2 A 92 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 A 92 2x39 G.H5 Y 358 G.H5.23
Polar TM3 A 158 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM2 T 90 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 90 2x37 G.H5 E 357 G.H5.22
Hydrophobic ICL2 M 163 - G.H5 I 350 G.H5.15
Hydrophobic TM3 R 155 3x50 G.H5 L 360 G.H5.25
Polar ICL2 R 169 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 169 - G.hns1 R 31 G.hns1.02
Polar H8 F 339 8x50 G.H5 N 359 G.H5.24
Hydrophobic H8 F 339 8x50 G.H5 N 359 G.H5.24
Van-der-waals H8 F 339 8x50 G.H5 N 359 G.H5.24
Polar TM6 E 265 6x30 G.H5 Q 352 G.H5.17
Polar TM3 R 155 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 M 163 - G.H5 K 347 G.H5.12
Hydrophobic ICL2 M 163 - G.S3 F 196 G.S3.03
Hydrophobic ICL2 R 167 - G.hns1 R 32 G.hns1.03
Hydrophobic TM2 L 96 2x43 G.H5 N 359 G.H5.24
Van-der-waals TM2 L 96 2x43 G.H5 N 359 G.H5.24
Hydrophobic TM6 A 268 6x33 G.H5 L 355 G.H5.20
Hydrophobic TM6 L 271 6x36 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 271 6x36 G.H5 L 360 G.H5.25
Hydrophobic ICL2 M 163 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 M 163 - G.S3 V 194 G.S3.01
Hydrophobic TM3 L 159 3x54 G.H5 L 360 G.H5.25
Hydrophobic TM7 V 333 7x54 G.H5 N 359 G.H5.24
Van-der-waals TM7 V 333 7x54 G.H5 N 359 G.H5.24
Polar H8 R 338 8x49 G.H5 R 356 G.H5.21
Hydrophobic H8 R 338 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 R 338 8x49 G.H5 R 356 G.H5.21
Van-der-waals TM4 R 172 4x40 G.HN Q 24 G.HN.48
Polar ICL2 G 166 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 G 166 - G.hns1 R 31 G.hns1.02
Ionic ICL2 R 169 - G.H5 E 357 G.H5.22
Polar TM5 N 254 5x68 G.H5 D 348 G.H5.13
Van-der-waals TM5 N 254 5x68 G.H5 D 348 G.H5.13
Hydrophobic ICL2 T 162 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 T 162 - G.H5 I 350 G.H5.15
Hydrophobic TM3 L 159 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 L 159 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM6 A 268 6x33 G.H5 L 360 G.H5.25