CCR5 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7O7F

RESOLUTION

3.2 Å

REFERENCE

10.1126/SCIADV.ABG8685

PUBLICATION DATE

June 30, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

85 interactions (Click to see)

LIGANDS

CCL5 - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

CCL11, CCL14, CCL2, CCL8, CCL5, CCL16, CCL4, CCL13, CCL7, CCL3



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 134 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 A 133 34x50 G.H5 I 344 G.H5.16
Ionic ICL2 R 140 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 140 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 134 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 C 224 5x68 G.H5 F 354 G.H5.26
Van-der-waals H8 E 302 8x48 G.H5 D 350 G.H5.22
Hydrophobic H8 E 302 8x48 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 L 353 G.H5.25
Ionic ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 137 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 137 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 A 133 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 133 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 I 237 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 130 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 221 5x65 G.H5 F 354 G.H5.26
Ionic TM5 R 223 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 223 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 223 5x67 G.H5 D 341 G.H5.13
Hydrophobic ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 V 300 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 300 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 233 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 229 6x29 G.H5 K 349 G.H5.21
Hydrophobic ICL3 R 225 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 I 217 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 R 223 5x67 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 223 5x67 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 233 6x33 G.H5 F 354 G.H5.26
Hydrophobic H8 E 302 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 302 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 130 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 221 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 221 5x65 G.H5 L 348 G.H5.20
Polar TM6 K 229 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 T 220 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 229 6x29 G.H5 F 354 G.H5.26
Polar TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic H8 K 303 8x49 G.H5 K 349 G.H5.21