MC4 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

γ-MSH, agouti-related protein, β-MSH, α-MSH, ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
Q52G.HNQ16R17Q22Y23G.H5GproteinI3x54Y2x40N34x55T4x38T6x36H5x68GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.H5GPCR segments:TM2ICL2TM3TM4TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x403x503x533x5434x5034x5134x5234x5434x554x385x615x625x655x685x695x715x726x326x336x366x377x56G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.h4s6.20G.h4s6.03G.H4.16G.S3.01G.s2s3.01G.S1.02G.hns1.03G.hns1.02G.HN.52Res. Pos.MC4 (7PIV)- (7PIV)------------------------MYRTIALQHNTMFAHIRIKGTLRMYALQHNRTITMFAHIRIKGTLRLYQIQFCRHVDRAQHLLLDRYELT

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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