VPAC2 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

May 18, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PACAP-27 (Human) - Agonist pubchem gtoplig uniprot uniprot uniprot uniprot pubchem

PHYSIOLOGICAL LIGANDS

VIP (Human), GHRH (Rat), secretin (Mouse), GHRH (Mouse), PHI (Mouse), GHRH (Human), PACAP-38 (Human), secretin (Rat), secretin (Pig), PACAP-27 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 M 234 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 310 5x65 G.H5 L 394 G.H5.26
Polar TM3 L 230 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 230 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 H 387 G.H5.19
Polar TM2 R 158 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 158 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM6 L 333 6x45 G.H5 L 393 G.H5.25
Polar TM6 S 329 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 329 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 329 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 231 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 231 3x58 G.H5 L 388 G.H5.20
Van-der-waals ICL2 L 235 - G.s2s3 K 216 G.s2s3.02
Van-der-waals H8 N 379 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 235 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 306 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 306 5x61 G.H5 L 393 G.H5.25
Polar TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM2 H 162 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM4 R 238 4x40 G.HN Q 35 G.HN.52
Polar TM6 R 325 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 325 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 325 6x37 G.H5 L 394 G.H5.26
Hydrophobic H8 E 381 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 E 381 8x49 G.H5 Q 390 G.H5.22
Ionic TM5 K 309 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 309 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 309 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 309 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Polar H8 S 380 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 380 8x48 G.H5 E 392 G.H5.24
Polar TM5 K 309 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 309 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 332 6x44 G.H5 E 392 G.H5.24
Van-der-waals H8 E 381 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 306 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM2 R 158 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 158 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 231 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 309 5x64 G.H5 R 385 G.H5.17