SST2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WJ5

RESOLUTION

3.7 Å

REFERENCE

10.7554/ELIFE.76823

PUBLICATION DATE

July 13, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

63 interactions (Click to see)

LIGANDS

SOMATOSTATIN - Agonist chembl_ligand pubchem drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14 (Mouse), SRIF-14 (Human), SRIF-28 (Human), CST-17 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 254 6x33 G.H5 L 348 G.H5.20
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 K 234 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 234 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 235 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 235 5x65 G.H5 L 348 G.H5.20
Polar ICL3 R 241 - G.h4s6 E 318 G.h4s6.12
Ionic ICL3 R 241 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 241 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 144 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 144 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 G 243 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 G 243 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Polar H8 N 318 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 N 318 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 318 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL3 V 242 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 A 151 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 235 5x65 G.H5 I 344 G.H5.16
Polar H8 D 317 8x48 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 148 - G.hns1 R 32 G.hns1.03
Polar ICL3 S 244 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 S 244 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 S 244 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 I 148 - G.S3 L 194 G.S3.01
Polar TM5 S 238 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 238 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 238 5x68 G.H5 D 341 G.H5.13
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 147 - G.H5 I 344 G.H5.16
Hydrophobic TM6 M 257 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 246 6x25 G.S6 Y 320 G.S6.02
Van-der-waals TM6 K 246 6x25 G.S6 Y 320 G.S6.02
Hydrophobic ICL3 I 240 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 I 240 - G.H5 D 337 G.H5.09
Hydrophobic TM6 V 254 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 231 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL3 R 241 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 241 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 R 241 - G.H5 A 338 G.H5.10
Polar TM6 S 245 6x24 G.S6 Y 320 G.S6.02
Van-der-waals TM6 S 245 6x24 G.S6 Y 320 G.S6.02
Polar H8 N 318 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 N 318 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 318 8x49 G.H5 D 350 G.H5.22
Ionic TM6 K 246 6x25 G.H5 D 341 G.H5.13
Polar TM6 K 246 6x25 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 246 6x25 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 246 6x25 G.H5 D 341 G.H5.13
Hydrophobic TM4 R 155 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 155 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 K 253 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM4 R 155 4x38 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 147 - G.H5 I 343 G.H5.15