Y2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7YOO

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.STR.2022.11.010

PUBLICATION DATE

March 22, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

81 interactions (Click to see)

LIGANDS

NEUROPEPTIDE-Y - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

neuropeptide Y (Human), neuropeptide Y-(3-36) (Human), pancreatic polypeptide (Rat), pancreatic polypeptide (Human), peptide YY (Human), pancreatic polypeptide (Mouse), PYY-(3-36) (Human), peptide YY (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Polar ICL2 H 155 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 H 155 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 H 155 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 H 249 - G.H5 I 344 G.H5.16
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Polar TM3 C 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 151 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 P 252 - G.H5 A 338 G.H5.10
Hydrophobic H8 N 329 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 P 252 - G.H5 F 334 G.H5.06
Hydrophobic H8 S 330 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL3 P 252 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 252 - G.S6 Y 320 G.S6.02
Polar TM3 C 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 155 - G.H5 I 343 G.H5.15
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 148 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 Y 259 6x26 G.H5 F 354 G.H5.26
Hydrophobic TM6 Y 259 6x26 G.H5 K 345 G.H5.17
Polar H8 S 330 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 S 330 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 S 330 8x48 G.H5 G 352 G.H5.24
Polar H8 N 331 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 331 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 R 263 6x30 G.H5 F 354 G.H5.26
Polar ICL3 S 251 - G.H5 K 345 G.H5.17
Polar H8 N 331 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 331 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 A 255 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 255 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 P 252 - G.H5 D 337 G.H5.09
Polar H8 N 329 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM5 K 245 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 P 252 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 P 252 - G.H5 D 341 G.H5.13
Hydrophobic TM5 L 246 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 262 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 156 - G.S3 L 194 G.S3.01
Ionic ICL2 K 159 - G.H5 D 350 G.H5.22
Polar ICL2 K 159 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 159 - G.H5 D 350 G.H5.22
Polar ICL3 S 251 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 251 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 251 - G.H5 D 341 G.H5.13
Ionic ICL3 H 249 - G.H5 D 341 G.H5.13
Polar ICL3 H 249 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 249 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 249 - G.H5 D 341 G.H5.13