NTS1 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Rattus norvegicus

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

March 29, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

neurotensin - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig ,

CHEMBL4576388 - PAM chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

neuromedin N, neurotensin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 P 174 34x50 G.H5 I 214 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 214 G.H5.15
Hydrophobic ICL2 P 174 34x50 G.H5 I 215 G.H5.16
Van-der-waals ICL2 P 174 34x50 G.H5 I 215 G.H5.16
Hydrophobic ICL2 F 175 34x51 G.S3 L 76 G.S3.01
Van-der-waals ICL2 F 175 34x51 G.S3 L 76 G.S3.01
Van-der-waals ICL2 P 174 34x50 G.H5 N 218 G.H5.19
Hydrophobic TM2 V 102 2x39 G.H5 C 222 G.H5.23
Van-der-waals TM2 V 102 2x39 G.H5 C 222 G.H5.23
Hydrophobic TM7 V 372 7x56 G.H5 L 224 G.H5.25
Van-der-waals TM7 V 372 7x56 G.H5 L 224 G.H5.25
Hydrophobic TM3 R 167 3x50 G.H5 L 219 G.H5.20
Hydrophobic ICL2 F 175 34x51 G.S1 V 31 G.S1.02
Polar TM3 A 170 3x53 G.H5 N 218 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 218 G.H5.19
Hydrophobic ICL2 F 175 34x51 G.H5 V 210 G.H5.11
Van-der-waals ICL2 F 175 34x51 G.H5 V 210 G.H5.11
Hydrophobic ICL2 F 175 34x51 G.H5 T 211 G.H5.12
Van-der-waals ICL2 F 175 34x51 G.H5 T 211 G.H5.12
Hydrophobic TM3 I 171 3x54 G.H5 L 219 G.H5.20
Hydrophobic ICL2 F 175 34x51 G.H5 I 214 G.H5.15
Polar C-term A 374 - G.H5 L 224 G.H5.25
Hydrophobic C-term A 374 - G.H5 L 224 G.H5.25
Van-der-waals C-term A 374 - G.H5 L 224 G.H5.25
Hydrophobic TM6 L 303 6x30 G.H5 L 219 G.H5.20
Polar C-term A 374 - G.H5 G 223 G.H5.24
Polar TM3 R 167 3x50 G.H5 C 222 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 222 G.H5.23
Van-der-waals TM3 R 167 3x50 G.H5 C 222 G.H5.23
Hydrophobic TM3 I 171 3x54 G.H5 I 215 G.H5.16
Hydrophobic C-term S 373 - G.H5 L 224 G.H5.25
Van-der-waals C-term S 373 - G.H5 L 224 G.H5.25
Hydrophobic ICL2 T 179 34x55 G.hns1 A 28 G.hns1.02
Van-der-waals ICL2 T 179 34x55 G.hns1 A 28 G.hns1.02
Polar C-term S 373 - G.H5 G 223 G.H5.24
Van-der-waals C-term S 373 - G.H5 G 223 G.H5.24