GPR20 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HS3

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41421-023-00520-8

PUBLICATION DATE

March 8, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 F 354 G.H5.26
Polar TM6 G 232 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 G 232 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 G 232 6x26 G.H5 D 341 G.H5.13
Polar TM3 I 152 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 152 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 152 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 235 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 A 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 242 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 238 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Ionic TM6 R 235 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 235 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 229 6x23 G.S6 Y 320 G.S6.02
Van-der-waals TM6 L 229 6x23 G.S6 Y 320 G.S6.02
Ionic TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 152 3x54 G.H5 C 351 G.H5.23
Ionic TM6 R 236 6x30 G.H5 D 341 G.H5.13
Polar H8 S 302 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 S 302 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 302 8x48 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 231 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 A 151 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 G 157 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 157 - G.hns1 R 32 G.hns1.03
Polar TM3 A 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x37 G.H5 L 353 G.H5.25
Polar H8 T 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 T 301 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 T 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 239 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 R 236 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 223 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 235 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 235 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 228 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 228 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 229 6x23 G.H5 D 337 G.H5.09
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 Q 231 6x25 G.S6 Y 320 G.S6.02
Polar TM6 Q 231 6x25 G.S6 I 319 G.S6.01
Van-der-waals TM6 Q 231 6x25 G.S6 I 319 G.S6.01
Hydrophobic TM6 L 229 6x23 G.H5 F 334 G.H5.06
Polar TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 C 351 G.H5.23
Polar TM2 S 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 88 2x39 G.H5 C 351 G.H5.23