GPR156 - Go

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IED

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Feb. 14, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

54 interactions (Click to see)

LIGANDS

PC 34:1 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 152 - G.H5 I 217 G.H5.15
Polar ICL2 V 158 - G.H5 N 221 G.H5.19
Hydrophobic ICL2 V 158 - G.H5 N 221 G.H5.19
Van-der-waals ICL2 V 158 - G.H5 N 221 G.H5.19
Hydrophobic ICL1 M 82 12x52 G.H5 L 227 G.H5.25
Hydrophobic ICL1 R 78 12x48 G.H5 Y 228 G.H5.26
Hydrophobic C-term F 332 - G.H5 A 219 G.H5.17
Hydrophobic ICL2 P 154 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 P 154 - G.S1 V 34 G.S1.02
Hydrophobic TM3 F 149 3x58 G.H5 L 222 G.H5.20
Polar ICL2 R 152 - G.H5 T 214 G.H5.12
Van-der-waals ICL2 R 152 - G.H5 T 214 G.H5.12
Hydrophobic ICL2 P 154 - G.S3 L 79 G.S3.01
Hydrophobic C-term I 325 - G.S6 Y 194 G.S6.02
Hydrophobic ICL2 P 154 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term I 325 - G.h4s6 E 192 G.h4s6.12
Van-der-waals C-term I 325 - G.h4s6 E 192 G.h4s6.12
Hydrophobic ICL1 K 81 12x51 G.H5 L 227 G.H5.25
Van-der-waals ICL1 K 81 12x51 G.H5 L 227 G.H5.25
Polar TM3 V 148 3x57 G.H5 N 221 G.H5.19
Hydrophobic TM3 V 148 3x57 G.H5 N 221 G.H5.19
Hydrophobic ICL2 P 154 - G.h2s4 T 104 G.h2s4.05
Hydrophobic ICL2 V 153 - G.H5 I 217 G.H5.15
Hydrophobic C-term F 332 - G.H5 D 215 G.H5.13
Van-der-waals C-term F 332 - G.H5 D 215 G.H5.13
Hydrophobic ICL2 R 152 - G.H5 I 218 G.H5.16
Van-der-waals ICL2 R 152 - G.H5 I 218 G.H5.16
Hydrophobic ICL2 P 154 - G.S1 D 33 G.S1.01
Van-der-waals ICL2 P 154 - G.S1 D 33 G.S1.01
Hydrophobic ICL1 M 82 12x52 G.H5 L 222 G.H5.20
Van-der-waals ICL1 M 82 12x52 G.H5 L 222 G.H5.20
Hydrophobic TM4 K 161 4x28 G.H5 C 225 G.H5.23
Van-der-waals ICL2 D 155 - G.h2s4 D 102 G.h2s4.03
Hydrophobic C-term F 332 - G.H5 I 218 G.H5.16
Van-der-waals C-term F 332 - G.H5 I 218 G.H5.16
Polar ICL1 K 81 12x51 G.H5 G 226 G.H5.24
Van-der-waals ICL1 K 81 12x51 G.H5 G 226 G.H5.24
Hydrophobic ICL2 I 159 - G.H5 C 225 G.H5.23
Hydrophobic C-term I 325 - G.H5 Y 228 G.H5.26
Van-der-waals C-term I 325 - G.H5 Y 228 G.H5.26
Hydrophobic C-term R 326 - G.S6 Y 194 G.S6.02
Van-der-waals C-term R 326 - G.S6 Y 194 G.S6.02
Hydrophobic TM3 V 148 3x57 G.H5 L 222 G.H5.20
Hydrophobic ICL2 P 154 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 154 - G.hns1 A 31 G.hns1.02
Ionic C-term R 326 - G.h4s6 E 192 G.h4s6.12
Polar C-term R 326 - G.h4s6 E 192 G.h4s6.12
Polar TM3 R 144 3x53 G.H5 C 225 G.H5.23
Hydrophobic TM3 R 144 3x53 G.H5 C 225 G.H5.23
Van-der-waals TM3 R 144 3x53 G.H5 C 225 G.H5.23
Polar ICL2 R 157 - G.H5 N 220 G.H5.18
Hydrophobic ICL2 R 157 - G.H5 N 220 G.H5.18
Van-der-waals ICL2 R 157 - G.H5 N 220 G.H5.18
Van-der-waals TM4 K 161 4x28 G.H5 G 224 G.H5.22
Hydrophobic TM3 R 144 3x53 G.H5 L 227 G.H5.25
Van-der-waals TM3 R 144 3x53 G.H5 L 227 G.H5.25
Ionic ICL2 D 155 - G.S1 K 35 G.S1.03
Polar ICL2 D 155 - G.S1 K 35 G.S1.03
Hydrophobic ICL2 I 159 - G.H5 G 224 G.H5.22
Van-der-waals ICL2 I 159 - G.H5 G 224 G.H5.22
Ionic ICL2 R 157 - G.h3s5 D 136 G.h3s5.02
Polar ICL2 R 157 - G.h3s5 D 136 G.h3s5.02
Van-der-waals ICL2 R 157 - G.h3s5 D 136 G.h3s5.02
Polar ICL2 I 160 - G.H5 C 225 G.H5.23
Hydrophobic ICL2 I 160 - G.H5 C 225 G.H5.23
Van-der-waals ICL2 I 160 - G.H5 C 225 G.H5.23
Polar ICL2 V 158 - G.H5 C 225 G.H5.23
Hydrophobic ICL2 V 158 - G.H5 C 225 G.H5.23
Van-der-waals ICL2 V 158 - G.H5 C 225 G.H5.23
Hydrophobic ICL2 V 153 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 R 157 - G.H5 R 223 G.H5.21
Hydrophobic TM3 F 149 3x58 G.H5 I 218 G.H5.16
Hydrophobic ICL1 S 83 12x53 G.H5 L 227 G.H5.25
Van-der-waals ICL1 S 83 12x53 G.H5 L 227 G.H5.25
Hydrophobic C-term F 332 - G.H5 L 222 G.H5.20
Van-der-waals C-term F 332 - G.H5 L 222 G.H5.20
Hydrophobic C-term F 332 - G.H5 Y 228 G.H5.26
Hydrophobic ICL2 V 153 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 153 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 V 148 3x57 G.H5 C 225 G.H5.23