NK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8U26

RESOLUTION

2.5 Å

REFERENCE

10.1038/S41592-023-02082-9

PUBLICATION DATE

Nov. 15, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

75 interactions (Click to see)

LIGANDS

substance P - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

PHYSIOLOGICAL LIGANDS

neuropeptide-γ, hemokinin 1, neurokinin A, neuropeptide K, neurokinin B, substance P



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 137 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 137 - G.H5 H 387 G.H5.19
Van-der-waals TM6 Q 239 6x26 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 138 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 138 - G.S3 V 217 G.S3.01
Hydrophobic TM7 L 308 7x56 G.H5 L 394 G.H5.26
Hydrophobic TM2 T 67 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 67 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 129 3x49 G.H5 Y 391 G.H5.23
Polar TM3 A 133 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 H 387 G.H5.19
Polar ICL2 L 138 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 138 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 138 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 138 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 138 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 P 140 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 P 140 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 137 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 137 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 137 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 137 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 R 130 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 133 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 223 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 138 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 L 138 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 138 - G.H5 R 380 G.H5.12
Hydrophobic H8 F 312 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 312 8x50 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 134 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 134 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL1 M 63 12x50 G.H5 E 392 G.H5.24
Van-der-waals ICL1 M 63 12x50 G.H5 E 392 G.H5.24
Polar TM3 I 135 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 I 135 3x55 G.H5 R 380 G.H5.12
Polar TM2 N 68 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 N 68 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 N 68 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 V 246 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 246 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 134 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 138 - G.H5 C 379 G.H5.11
Polar ICL2 R 141 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 141 - G.H5 Y 391 G.H5.23
Hydrophobic H8 N 309 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 309 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 140 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 K 243 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 138 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 138 - G.H5 I 383 G.H5.15