OR51G2 - Gs

GPCR CLASS (FAMILY)

Class O1 (fish-like odorant)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8UXV

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41586-024-08126-0

PUBLICATION DATE

Oct. 30, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 C 242 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 E 234 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 E 234 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 T 241 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 241 6x36 G.H5 L 393 G.H5.25
Hydrophobic H8 T 297 8x47 G.H5 E 392 G.H5.24
Polar ICL2 Y 133 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 126 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 M 60 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 222 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 222 5x61 G.H5 L 393 G.H5.25
Polar TM3 A 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 226 5x65 G.H5 L 388 G.H5.20
Polar ICL2 R 132 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 132 - G.s2s3 D 215 G.s2s3.01
Polar TM6 K 237 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 131 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 131 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 131 - G.H5 I 383 G.H5.15
Hydrophobic TM3 I 127 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 127 3x54 G.H5 L 393 G.H5.25
Ionic H8 K 298 8x48 G.H5 E 392 G.H5.24
Polar H8 K 298 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 298 8x48 G.H5 E 392 G.H5.24
Polar TM6 T 241 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 130 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 130 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 131 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 130 - G.H5 R 380 G.H5.12
Polar TM6 A 238 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 134 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 132 - G.S3 V 217 G.S3.01
Hydrophobic ICL3 I 229 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 I 229 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 130 - G.H5 H 387 G.H5.19
Hydrophobic ICL4 K 296 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 K 296 - G.H5 E 392 G.H5.24
Polar TM3 I 127 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 130 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 130 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 131 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 131 - G.H5 F 376 G.H5.08
Aromatic ICL2 Y 133 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 133 - G.H5 H 387 G.H5.19
Polar TM3 D 122 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 122 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 122 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 131 - G.H5 C 379 G.H5.11
Hydrophobic ICL3 I 229 - G.H5 L 388 G.H5.20
Hydrophobic TM3 I 127 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 L 131 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 131 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 131 - G.S1 H 41 G.S1.02
Hydrophobic ICL3 I 229 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 I 229 - G.H5 Q 384 G.H5.16
Polar TM3 C 128 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM2 M 60 2x39 G.H5 Q 390 G.H5.22