A3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

8X16

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41467-024-47207-6

PUBLICATION DATE

April 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

42 interactions (Click to see)

LIGANDS

piclidenoson - Agonist pubchem gtoplig chembl_ligand chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 116 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 204 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 204 5x65 G.H5 L 348 G.H5.20
Polar TM7 K 285 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM7 K 285 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 K 285 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 I 286 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 I 286 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 I 286 8x47 G.H5 C 351 G.H5.23
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Polar H8 K 287 8x48 G.H5 G 352 G.H5.24
Polar ICL1 T 47 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 T 47 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 T 47 - G.H5 D 350 G.H5.22
Hydrophobic TM5 L 208 5x69 G.H5 K 345 G.H5.17
Van-der-waals TM5 L 208 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM6 R 224 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 224 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 228 6x33 G.H5 L 353 G.H5.25
Polar H8 K 287 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 K 287 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 K 287 8x48 G.H5 K 349 G.H5.21
Polar TM6 T 228 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 228 6x33 G.H5 F 354 G.H5.26
Hydrophobic H8 K 287 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 K 287 8x48 G.H5 L 353 G.H5.25
Polar ICL1 T 47 - G.H5 C 351 G.H5.23
Hydrophobic ICL1 T 47 - G.H5 C 351 G.H5.23
Van-der-waals ICL1 T 47 - G.H5 C 351 G.H5.23
Hydrophobic TM3 V 112 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Ionic H8 K 288 8x49 G.H5 D 350 G.H5.22
Polar H8 K 288 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 288 8x49 G.H5 D 350 G.H5.22
Polar ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM7 K 285 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 K 285 7x56 G.H5 G 352 G.H5.24
Polar ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 R 224 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 227 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 227 6x32 G.H5 L 353 G.H5.25
Ionic TM3 R 111 3x53 G.H5 D 350 G.H5.22
Polar TM3 R 111 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 111 3x53 G.H5 D 350 G.H5.22
Hydrophobic ICL1 T 45 - G.H5 D 350 G.H5.22
Hydrophobic TM6 S 231 6x36 G.H5 L 353 G.H5.25
Ionic TM6 R 224 6x29 G.h4s6 E 318 G.h4s6.12