SST3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XIQ

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

July 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

63 interactions (Click to see)

LIGANDS

L-796,778 - Agonist pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14 (Mouse), SRIF-14 (Human), SRIF-28 (Human), CST-17 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 153 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 R 153 - G.HN Q 28 G.HN.52
Hydrophobic TM6 R 254 6x32 G.H5 F 361 G.H5.26
Van-der-waals TM6 R 254 6x32 G.H5 F 361 G.H5.26
Hydrophobic TM6 V 255 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 255 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM5 V 233 5x65 G.H5 L 355 G.H5.20
Polar TM3 A 144 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 354 G.H5.19
Ionic H8 R 319 8x49 G.H5 D 357 G.H5.22
Polar H8 R 319 8x49 G.H5 D 357 G.H5.22
Hydrophobic H8 R 319 8x49 G.H5 D 357 G.H5.22
Van-der-waals H8 R 319 8x49 G.H5 D 357 G.H5.22
Hydrophobic TM5 V 240 5x72 G.H5 D 348 G.H5.13
Hydrophobic ICL3 W 241 - G.S6 P 328 G.S6.03
Van-der-waals ICL3 W 241 - G.S6 P 328 G.S6.03
Hydrophobic ICL3 Q 246 - G.h4s6 T 317 G.h4s6.03
Van-der-waals ICL3 Q 246 - G.h4s6 T 317 G.h4s6.03
Hydrophobic H8 S 317 8x47 G.H5 G 359 G.H5.24
Aromatic H8 Y 318 8x48 G.H5 R 356 G.H5.21
Hydrophobic H8 Y 318 8x48 G.H5 R 356 G.H5.21
Van-der-waals H8 Y 318 8x48 G.H5 R 356 G.H5.21
Hydrophobic TM3 A 144 3x53 G.H5 C 358 G.H5.23
Hydrophobic ICL3 S 244 - G.H4 L 313 G.H4.16
Van-der-waals ICL3 S 244 - G.H4 L 313 G.H4.16
Van-der-waals ICL2 P 148 - G.H5 N 354 G.H5.19
Hydrophobic TM3 R 141 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM5 V 233 5x65 G.H5 I 351 G.H5.16
Hydrophobic ICL3 S 244 - G.S6 P 328 G.S6.03
Hydrophobic TM5 V 240 5x72 G.S6 Y 327 G.S6.02
Van-der-waals TM5 V 240 5x72 G.S6 Y 327 G.S6.02
Van-der-waals ICL3 W 241 - G.H5 K 352 G.H5.17
Hydrophobic H8 Y 318 8x48 G.H5 F 361 G.H5.26
Van-der-waals H8 Y 318 8x48 G.H5 F 361 G.H5.26
Polar ICL3 W 241 - G.S6 C 326 G.S6.01
Hydrophobic ICL3 W 241 - G.S6 C 326 G.S6.01
Van-der-waals ICL3 W 241 - G.S6 C 326 G.S6.01
Hydrophobic ICL2 P 148 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 148 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 T 149 - G.hns1 A 32 G.hns1.03
Hydrophobic TM3 V 145 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM5 V 240 5x72 G.H5 D 345 G.H5.10
Van-der-waals TM5 V 240 5x72 G.H5 D 345 G.H5.10
Hydrophobic TM5 V 240 5x72 G.H5 N 344 G.H5.09
Hydrophobic TM6 V 255 6x33 G.H5 L 355 G.H5.20
Hydrophobic ICL3 W 241 - G.H5 D 348 G.H5.13
Van-der-waals ICL3 W 241 - G.H5 D 348 G.H5.13
Aromatic ICL3 W 241 - G.S6 Y 327 G.S6.02
Hydrophobic ICL3 W 241 - G.S6 Y 327 G.S6.02
Van-der-waals ICL3 W 241 - G.S6 Y 327 G.S6.02
Polar TM3 R 141 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 358 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 358 G.H5.23
Hydrophobic TM3 V 145 3x54 G.H5 N 354 G.H5.19
Hydrophobic TM5 A 236 5x68 G.H5 I 351 G.H5.16
Van-der-waals TM5 A 236 5x68 G.H5 I 351 G.H5.16
Hydrophobic TM6 M 258 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM5 K 232 5x64 G.H5 I 351 G.H5.16
Hydrophobic ICL3 P 243 - G.H4 R 309 G.H4.12