DP2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XXV

RESOLUTION

2.3 Å

REFERENCE

PUBLICATION DATE

Dec. 4, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

75 interactions (Click to see)

LIGANDS

Phosphatidylinositol (16:0/18:1) - PAM ,

indomethacin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

PGF2α, Δ12-PGJ2, PGE2, PGD2, PGI2, PGD3, thromboxane A2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 129 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 Q 132 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 Q 132 3x53 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 136 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 136 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM7 T 307 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 307 7x56 G.H5 G 352 G.H5.24
Polar ICL2 N 141 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 141 34x55 G.s2s3 D 193 G.s2s3.02
Polar H8 C 308 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 C 308 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 C 308 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM6 F 244 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 233 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 133 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 133 3x54 G.H5 L 348 G.H5.20
Ionic ICL3 R 236 - G.H5 D 341 G.H5.13
Polar ICL3 R 236 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 238 - G.H5 K 345 G.H5.17
Polar TM6 R 243 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 243 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 243 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 233 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 247 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 136 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 137 34x51 G.H5 F 336 G.H5.08
Polar TM6 F 244 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 244 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 244 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 R 239 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 239 - G.H5 F 354 G.H5.26
Polar TM6 R 243 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 243 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 243 6x32 G.H5 F 354 G.H5.26
Ionic ICL3 R 238 - G.H5 D 341 G.H5.13
Polar ICL3 R 238 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 D 341 G.H5.13
Polar ICL3 R 236 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 R 236 - G.H5 T 340 G.H5.12
Polar TM6 R 243 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 243 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 R 243 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 137 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 137 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 N 141 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 141 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 247 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 247 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM4 V 145 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 V 145 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 P 241 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 P 241 6x30 G.H5 F 354 G.H5.26
Polar ICL3 R 238 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 238 - G.S6 Y 320 G.S6.02
Polar ICL2 Q 140 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 140 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM4 T 144 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 144 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 133 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 133 3x54 G.H5 I 344 G.H5.16
Polar H8 C 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 C 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 C 308 8x47 G.H5 G 352 G.H5.24
Polar TM3 R 129 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 137 34x51 G.S3 L 194 G.S3.01
Polar H8 C 308 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 C 308 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 C 308 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL2 Q 140 34x54 G.hns1 R 32 G.hns1.03
Ionic ICL3 R 238 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 238 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 238 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 238 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 Q 132 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 140 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 140 34x54 G.H5 I 343 G.H5.15