chemerin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZJG

RESOLUTION

3.2 Å

REFERENCE

10.1038/S42003-024-07228-9

PUBLICATION DATE

Jan. 22, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

109 interactions (Click to see)

LIGANDS

Chemerin - Agonist

PHYSIOLOGICAL LIGANDS

18R-HEPE, EPA, resolvin E1, chemerin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Q 148 34x54 G.H5 I 343 G.H5.15
Polar TM6 P 258 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 258 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 258 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 252 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 252 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 145 34x51 G.S3 L 194 G.S3.01
Polar ICL2 N 149 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 149 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 Y 240 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 261 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 243 5x61 G.H5 L 353 G.H5.25
Polar ICL2 R 151 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 151 34x57 G.hns1 R 32 G.hns1.03
Polar TM3 S 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 145 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 L 247 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 247 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 A 253 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 A 253 - G.H5 F 354 G.H5.26
Polar ICL3 K 254 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 K 254 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 K 254 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 K 246 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 262 6x37 G.H5 L 353 G.H5.25
Polar ICL2 N 149 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 149 34x55 G.hns1 R 32 G.hns1.03
Polar TM2 N 74 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 252 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 252 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 145 34x51 G.H5 F 336 G.H5.08
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 144 34x50 G.H5 T 340 G.H5.12
Polar ICL3 K 254 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 K 254 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 P 258 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 145 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Polar ICL2 Q 148 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 148 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 144 34x50 G.H5 I 344 G.H5.16