ADGRD1 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

Feb. 12, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

dihydrotestosterone - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

dihydrotestosterone



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 F 665 - G.S3 V 217 G.S3.01
Polar TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 601 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 V 661 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 661 3x58 G.H5 L 388 G.H5.20
Aromatic ICL2 F 665 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 665 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 665 - G.H5 F 376 G.H5.08
Hydrophobic TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 657 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 664 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 664 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 664 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 V 664 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 664 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 734 5x57 G.H5 L 393 G.H5.25
Aromatic TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 601 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 665 - G.H5 R 380 G.H5.12
Hydrophobic TM7 L 809 7x60 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 809 7x60 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 667 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 S 667 - G.H5 H 387 G.H5.19
Polar TM3 M 660 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 M 660 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 M 660 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 761 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 737 5x60 G.H5 L 388 G.H5.20
Polar H8 S 811 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 M 660 3x57 G.H5 Y 391 G.H5.23
Hydrophobic H8 N 810 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 738 5x61 G.H5 L 393 G.H5.25
Polar H8 E 812 8x49 G.H5 Q 390 G.H5.22
Polar TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 661 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 661 3x58 G.H5 Q 384 G.H5.16