P2Y14 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9J0F

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41421-025-00799-9

PUBLICATION DATE

June 4, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

58 interactions (Click to see)

LIGANDS

NADH - Agonist pubchem drugbank

PHYSIOLOGICAL LIGANDS

UDP, UDP-galactose, UDP-glucose, UDP N-acetyl-glucosamine, UDP-glucuronic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 H 217 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 H 217 - G.H5 I 344 G.H5.16
Hydrophobic TM6 N 223 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 223 6x26 G.H5 K 345 G.H5.17
Polar TM3 K 122 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 122 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 122 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 C 351 G.H5.23
Polar TM6 S 226 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 I 123 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 123 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 230 6x33 G.H5 F 354 G.H5.26
Polar TM3 K 122 3x53 G.H5 N 347 G.H5.19
Polar TM6 N 223 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 223 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 223 6x26 G.h4s6 E 318 G.h4s6.12
Ionic ICL3 K 219 - G.H5 D 341 G.H5.13
Polar ICL3 K 219 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 219 - G.H5 D 341 G.H5.13
Polar ICL3 H 217 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL3 K 219 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 219 - G.h4s6 E 318 G.h4s6.12
Polar TM3 K 122 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM6 I 235 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 235 6x38 G.H5 L 353 G.H5.25
Polar TM6 S 224 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 L 298 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 298 7x56 G.H5 G 352 G.H5.24
Polar TM6 N 223 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 N 223 6x26 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 N 223 6x26 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL3 K 219 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 219 - G.S6 Y 320 G.S6.02
Polar TM3 R 119 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 119 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 123 3x54 G.H5 L 348 G.H5.20
Polar ICL3 H 217 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 H 217 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 H 217 - G.H5 K 345 G.H5.17
Polar TM6 N 223 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 S 231 6x34 G.H5 L 348 G.H5.20
Polar TM6 N 234 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 234 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 234 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 223 6x26 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 V 227 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 238 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 238 6x41 G.H5 L 353 G.H5.25
Polar TM6 S 221 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 221 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 221 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 F 56 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 56 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 F 56 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 119 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 227 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 227 6x30 G.H5 F 354 G.H5.26
Hydrophobic ICL3 S 216 - G.H5 I 344 G.H5.16
Hydrophobic TM5 I 213 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 227 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM5 I 209 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 231 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 N 347 G.H5.19