PrRP receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K27

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

Jan. 29, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

69 interactions (Click to see)

LIGANDS

PrRP31 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PrRP-20 (Human), PrRP-20 (Rat), neuropeptide Y (Human), PTHrP (Human), PrRP-31 (Rat), PrRP-31 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 167 - G.H5 K 339 G.H5.12
Hydrophobic ICL3 G 259 - G.H5 F 333 G.H5.06
Van-der-waals ICL3 G 259 - G.H5 F 333 G.H5.06
Hydrophobic ICL3 C 260 - G.S6 F 322 G.S6.05
Van-der-waals ICL3 C 260 - G.S6 F 322 G.S6.05
Hydrophobic ICL2 R 169 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 169 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 L 280 6x37 G.H5 L 352 G.H5.25
Hydrophobic TM5 R 255 5x68 G.H5 L 343 G.H5.16
Van-der-waals TM5 R 255 5x68 G.H5 L 343 G.H5.16
Hydrophobic ICL3 P 258 - G.H5 A 336 G.H5.09
Hydrophobic TM3 L 163 3x54 G.H5 L 352 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 352 G.H5.25
Hydrophobic ICL2 L 167 - G.S1 L 34 G.S1.02
Hydrophobic ICL3 P 258 - G.H5 D 340 G.H5.13
Hydrophobic TM6 R 272 6x29 G.H5 V 353 G.H5.26
Van-der-waals TM6 R 272 6x29 G.H5 V 353 G.H5.26
Ionic ICL2 R 170 - G.H5 E 349 G.H5.22
Polar ICL2 R 170 - G.H5 E 349 G.H5.22
Hydrophobic TM6 L 279 6x36 G.H5 L 352 G.H5.25
Polar ICL3 C 260 - G.S6 S 320 G.S6.03
Van-der-waals ICL3 C 260 - G.S6 S 320 G.S6.03
Hydrophobic ICL3 P 258 - G.H5 F 333 G.H5.06
Hydrophobic H8 F 342 8x50 G.H5 N 351 G.H5.24
Van-der-waals H8 F 342 8x50 G.H5 N 351 G.H5.24
Polar TM3 D 158 3x49 G.H5 Y 350 G.H5.23
Hydrophobic TM3 D 158 3x49 G.H5 Y 350 G.H5.23
Van-der-waals TM3 D 158 3x49 G.H5 Y 350 G.H5.23
Hydrophobic ICL2 P 166 - G.H5 K 339 G.H5.12
Hydrophobic ICL2 L 167 - G.S3 V 193 G.S3.01
Hydrophobic ICL3 P 258 - G.S6 Y 319 G.S6.02
Van-der-waals TM5 R 255 5x68 G.H5 Q 344 G.H5.17
Polar TM2 T 95 2x39 G.H5 E 349 G.H5.22
Hydrophobic ICL3 C 260 - G.H4 L 304 G.H4.12
Van-der-waals ICL3 C 260 - G.H4 L 304 G.H4.12
Polar TM6 R 272 6x29 G.H5 Q 344 G.H5.17
Van-der-waals TM6 R 272 6x29 G.H5 Q 344 G.H5.17
Polar ICL2 R 170 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 170 - G.hns1 R 31 G.hns1.02
Polar TM3 I 155 3x46 G.H5 Y 350 G.H5.23
Hydrophobic TM3 I 155 3x46 G.H5 Y 350 G.H5.23
Polar TM2 T 95 2x39 G.H5 Y 350 G.H5.23
Hydrophobic TM2 T 95 2x39 G.H5 Y 350 G.H5.23
Van-der-waals TM2 T 95 2x39 G.H5 Y 350 G.H5.23
Polar TM6 W 268 6x25 G.h4s6 D 315 G.h4s6.12
Hydrophobic TM6 W 268 6x25 G.h4s6 D 315 G.h4s6.12
Van-der-waals TM6 W 268 6x25 G.h4s6 D 315 G.h4s6.12
Hydrophobic TM3 L 163 3x54 G.H5 L 343 G.H5.16
Hydrophobic ICL2 P 166 - G.H5 I 342 G.H5.15
Van-der-waals ICL2 P 166 - G.H5 I 342 G.H5.15
Hydrophobic ICL2 P 166 - G.H5 L 343 G.H5.16
Polar ICL4 H 339 - G.H5 N 351 G.H5.24
Hydrophobic ICL4 H 339 - G.H5 N 351 G.H5.24
Van-der-waals ICL4 H 339 - G.H5 N 351 G.H5.24
Hydrophobic ICL2 L 167 - G.s2s3 S 192 G.s2s3.02
Polar TM6 T 276 6x33 G.H5 L 352 G.H5.25
Van-der-waals TM6 T 276 6x33 G.H5 L 352 G.H5.25
Hydrophobic ICL3 G 259 - G.S6 S 320 G.S6.03
Van-der-waals ICL3 G 259 - G.S6 S 320 G.S6.03
Hydrophobic TM3 R 159 3x50 G.H5 L 352 G.H5.25
Van-der-waals TM3 R 159 3x50 G.H5 L 352 G.H5.25
Hydrophobic TM6 Q 265 6x22 G.H4 V 308 G.H4.16
Van-der-waals TM6 Q 265 6x22 G.H4 V 308 G.H4.16
Hydrophobic ICL3 V 257 - G.S6 Y 319 G.S6.02
Polar TM2 N 93 2x37 G.H5 E 349 G.H5.22
Hydrophobic TM2 N 93 2x37 G.H5 E 349 G.H5.22
Van-der-waals TM2 N 93 2x37 G.H5 E 349 G.H5.22
Polar TM3 V 162 3x53 G.H5 N 346 G.H5.19
Hydrophobic TM3 V 162 3x53 G.H5 N 346 G.H5.19
Van-der-waals TM3 V 162 3x53 G.H5 N 346 G.H5.19
Hydrophobic ICL2 R 169 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 252 5x65 G.H5 L 347 G.H5.20
Ionic TM5 R 255 5x68 G.H5 D 340 G.H5.13
Polar TM5 R 255 5x68 G.H5 D 340 G.H5.13
Van-der-waals TM5 R 255 5x68 G.H5 D 340 G.H5.13
Hydrophobic ICL2 L 167 - G.H5 F 335 G.H5.08
Hydrophobic TM3 R 159 3x50 G.H5 Y 350 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 Y 350 G.H5.23
Hydrophobic TM3 L 163 3x54 G.H5 L 347 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 347 G.H5.20
Hydrophobic TM3 L 163 3x54 G.H5 N 346 G.H5.19