S1P3 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9L74

RESOLUTION

3.7 Å

REFERENCE

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

d16:1 S1P - Agonist pubchem

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 229 5x72 G.S6 Y 212 G.S6.02
Van-der-waals TM5 V 229 5x72 G.S6 Y 212 G.S6.02
Hydrophobic ICL1 H 71 12x51 G.H5 Y 243 G.H5.23
Van-der-waals ICL1 H 71 12x51 G.H5 Y 243 G.H5.23
Hydrophobic TM6 R 237 6x29 G.H5 V 246 G.H5.26
Polar TM2 R 73 2x38 G.H5 Y 243 G.H5.23
Polar ICL2 R 144 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 R 144 - G.H5 N 239 G.H5.19
Hydrophobic TM5 V 222 5x65 G.H5 L 240 G.H5.20
Van-der-waals TM5 V 222 5x65 G.H5 L 240 G.H5.20
Hydrophobic ICL2 M 143 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 M 143 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 M 143 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 M 143 - G.H5 K 232 G.H5.12
Polar ICL2 Y 146 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 Y 146 - G.H5 E 242 G.H5.22
Van-der-waals ICL2 Y 146 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 R 144 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 M 143 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 M 143 - G.H5 F 228 G.H5.08
Hydrophobic TM5 V 229 5x72 G.H5 D 230 G.H5.10
Van-der-waals TM5 V 229 5x72 G.H5 D 230 G.H5.10
Hydrophobic TM5 V 222 5x65 G.H5 L 236 G.H5.16
Hydrophobic TM3 M 140 3x54 G.H5 Y 243 G.H5.23
Van-der-waals TM3 M 140 3x54 G.H5 Y 243 G.H5.23
Hydrophobic TM6 L 242 6x34 G.H5 V 246 G.H5.26
Van-der-waals TM6 L 242 6x34 G.H5 V 246 G.H5.26
Hydrophobic TM5 V 229 5x72 G.H5 N 229 G.H5.09
Hydrophobic TM5 S 225 5x68 G.H5 L 236 G.H5.16
Polar TM6 H 232 6x24 G.H4 R 194 G.H4.12
Van-der-waals TM6 H 232 6x24 G.H4 R 194 G.H4.12
Polar ICL2 Y 146 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 Y 146 - G.H5 N 239 G.H5.19
Hydrophobic TM6 L 242 6x34 G.H5 L 245 G.H5.25
Van-der-waals TM6 L 242 6x34 G.H5 L 245 G.H5.25
Hydrophobic TM6 R 237 6x29 G.h4s6 G 207 G.h4s6.11
Polar TM3 T 139 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 T 139 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 T 139 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM5 V 229 5x72 G.H5 D 233 G.H5.13
Van-der-waals TM5 V 229 5x72 G.H5 D 233 G.H5.13
Polar TM3 E 135 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 T 139 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 M 143 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 M 143 - G.S3 F 81 G.S3.03
Hydrophobic TM6 V 245 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 V 245 6x37 G.H5 L 245 G.H5.25
Hydrophobic ICL2 M 143 - G.S3 V 79 G.S3.01
Hydrophobic TM5 I 218 5x61 G.H5 L 245 G.H5.25
Ionic ICL1 H 71 12x51 G.H5 E 242 G.H5.22
Polar ICL1 H 71 12x51 G.H5 E 242 G.H5.22
Hydrophobic ICL1 H 71 12x51 G.H5 E 242 G.H5.22
Van-der-waals ICL1 H 71 12x51 G.H5 E 242 G.H5.22
Hydrophobic TM6 N 231 6x23 G.h4s6 I 210 G.h4s6.20
Van-der-waals TM6 N 231 6x23 G.h4s6 I 210 G.h4s6.20
Hydrophobic TM6 L 241 6x33 G.H5 V 246 G.H5.26
Hydrophobic TM3 M 140 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 240 G.H5.20
Ionic ICL2 D 147 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 D 147 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 D 147 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 145 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 M 143 - G.H5 C 231 G.H5.11
Van-der-waals ICL2 M 143 - G.H5 C 231 G.H5.11
Hydrophobic TM3 M 140 3x54 G.H5 N 239 G.H5.19
Van-der-waals TM3 M 140 3x54 G.H5 N 239 G.H5.19