H1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

June 11, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM4 T 140 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 140 4x38 G.hns1 R 32 G.hns1.03
Polar TM6 A 413 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 413 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 220 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 220 5x68 G.H5 I 344 G.H5.16
Ionic TM5 H 220 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 220 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 220 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 220 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Polar TM6 Q 416 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 Q 416 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 Q 416 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 217 5x65 G.H5 L 348 G.H5.20
Polar TM6 K 412 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 412 6x32 G.H5 F 354 G.H5.26
Polar H8 N 472 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 N 472 8x47 G.H5 D 350 G.H5.22
Polar TM3 S 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 N 347 G.H5.19
Ionic ICL2 K 137 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 137 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 137 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 V 217 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 129 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 217 5x65 G.H5 L 353 G.H5.25
Polar TM6 Q 416 6x36 G.H5 C 351 G.H5.23
Hydrophobic TM6 Q 416 6x36 G.H5 C 351 G.H5.23
Van-der-waals TM6 Q 416 6x36 G.H5 C 351 G.H5.23
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 220 5x68 G.H5 F 354 G.H5.26
Van-der-waals TM5 H 220 5x68 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 132 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 132 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 133 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 133 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 132 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 417 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 417 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 133 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 133 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 133 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 133 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 133 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 133 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM6 Q 416 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 Q 416 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 C 221 5x69 G.H5 F 354 G.H5.26
Van-der-waals TM5 C 221 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 213 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 353 G.H5.25