GPR139 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Jan. 21, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Compound 1.1(S) - Agonist pubchem

PHYSIOLOGICAL LIGANDS

D-tryptophan, D-phenylalanine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM2 V 62 2x39 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 134 - G.H5 C 369 G.H5.11
Hydrophobic TM3 V 130 3x54 G.H5 L 374 G.H5.16
Van-der-waals TM3 V 130 3x54 G.H5 L 374 G.H5.16
Polar TM3 D 125 3x49 G.H5 Y 381 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 134 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 134 - G.H5 I 373 G.H5.15
Hydrophobic TM6 L 230 6x37 G.H5 L 383 G.H5.25
Hydrophobic TM3 V 130 3x54 G.H5 L 383 G.H5.25
Ionic ICL2 K 135 - G.s2s3 D 215 G.s2s3.01
Polar ICL2 K 135 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 P 133 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 133 - G.H5 I 373 G.H5.15
Polar ICL1 Q 59 12x53 G.hns1 R 38 G.hns1.02
Polar ICL2 H 137 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 137 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 137 - G.hns1 R 38 G.hns1.02
Polar H8 R 291 8x49 G.H5 R 379 G.H5.21
Van-der-waals H8 R 291 8x49 G.H5 R 379 G.H5.21
Hydrophobic TM6 I 229 6x36 G.H5 L 383 G.H5.25
Polar TM6 T 226 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 383 G.H5.25
Polar TM3 R 126 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 134 - G.H5 K 370 G.H5.12
Van-der-waals ICL2 L 134 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 L 134 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 134 - G.H5 F 366 G.H5.08
Polar TM6 T 226 6x33 G.H5 V 384 G.H5.26
Van-der-waals TM6 T 226 6x33 G.H5 V 384 G.H5.26
Hydrophobic TM3 V 130 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM3 A 129 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 L 383 G.H5.25
Polar TM3 A 129 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM6 K 225 6x32 G.H5 V 384 G.H5.26
Hydrophobic ICL2 P 133 - G.H5 L 374 G.H5.16
Polar ICL4 S 289 - G.H5 N 382 G.H5.24
Hydrophobic ICL4 S 289 - G.H5 N 382 G.H5.24
Van-der-waals ICL4 S 289 - G.H5 N 382 G.H5.24
Hydrophobic ICL2 L 134 - G.S3 V 217 G.S3.01
Hydrophobic TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL4 I 288 - G.H5 N 382 G.H5.24
Van-der-waals ICL4 I 288 - G.H5 N 382 G.H5.24