CT receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

9UWQ

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41401-025-01635-2

PUBLICATION DATE

May 27, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

96 interactions (Click to see)

LIGANDS

cagrilintide - Agonist pubchem gtoplig drugbank

PHYSIOLOGICAL LIGANDS

adrenomedullin 2/intermedin (Human), β-CGRP (Mouse), amylin (Mouse), α-CGRP (Human), calcitonin (Human), β-CGRP (Human), β-CGRP (Rat), α-CGRP (Mouse), calcitonin (Mouse), adrenomedullin (Human), amylin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 T 330 5x68 G.h4s6 Y 325 G.h4s6.20
Van-der-waals TM5 T 330 5x68 G.h4s6 Y 325 G.h4s6.20
Hydrophobic TM3 I 248 3x58 G.H5 H 354 G.H5.19
Hydrophobic TM5 K 326 5x64 G.H5 L 355 G.H5.20
Hydrophobic H8 N 396 8x48 G.H5 E 359 G.H5.24
Hydrophobic TM5 I 319 5x57 G.H5 L 360 G.H5.25
Hydrophobic ICL2 F 253 - G.H5 C 346 G.H5.11
Polar TM5 K 326 5x64 G.H5 R 352 G.H5.17
Hydrophobic TM5 K 326 5x64 G.H5 R 352 G.H5.17
Van-der-waals TM5 K 326 5x64 G.H5 R 352 G.H5.17
Hydrophobic TM6 A 344 6x41 G.H5 L 360 G.H5.25
Aromatic ICL2 F 253 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 F 253 - G.S1 H 34 G.S1.02
Polar TM6 K 340 6x37 G.H5 L 361 G.H5.26
Hydrophobic TM5 L 323 5x61 G.H5 L 361 G.H5.26
Hydrophobic ICL2 F 253 - G.H5 I 350 G.H5.15
Polar H8 E 397 8x49 G.H5 Q 357 G.H5.22
Hydrophobic H8 E 397 8x49 G.H5 Q 357 G.H5.22
Van-der-waals H8 E 397 8x49 G.H5 Q 357 G.H5.22
Polar TM3 I 248 3x58 G.H5 Q 351 G.H5.16
Hydrophobic TM6 I 347 6x44 G.H5 L 360 G.H5.25
Van-der-waals TM6 I 347 6x44 G.H5 L 360 G.H5.25
Polar TM3 L 247 3x57 G.H5 H 354 G.H5.19
Hydrophobic TM3 L 247 3x57 G.H5 H 354 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 H 354 G.H5.19
Ionic TM5 E 329 5x67 G.H5 R 352 G.H5.17
Polar TM5 E 329 5x67 G.H5 R 352 G.H5.17
Hydrophobic TM5 M 327 5x65 G.H5 L 361 G.H5.26
Hydrophobic ICL2 F 253 - G.H5 R 347 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 R 347 G.H5.12
Hydrophobic TM3 L 244 3x54 G.H5 Y 358 G.H5.23
Ionic ICL2 E 255 - G.hns1 R 31 G.hns1.02
Polar ICL2 E 255 - G.hns1 R 31 G.hns1.02
Polar ICL3 E 332 - G.h4s6 Y 325 G.h4s6.20
Van-der-waals ICL3 E 332 - G.h4s6 Y 325 G.h4s6.20
Hydrophobic ICL2 V 252 - G.H5 R 347 G.H5.12
Polar TM5 K 326 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM5 K 326 5x64 G.H5 Q 351 G.H5.16
Van-der-waals TM5 K 326 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM5 T 330 5x68 G.H5 R 352 G.H5.17
Van-der-waals TM5 T 330 5x68 G.H5 R 352 G.H5.17
Ionic ICL3 H 331 - G.hgh4 D 290 G.hgh4.13
Hydrophobic ICL2 V 252 - G.H5 Q 351 G.H5.16
Van-der-waals ICL2 V 252 - G.H5 Q 351 G.H5.16
Hydrophobic TM6 L 348 6x45 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 348 6x45 G.H5 L 360 G.H5.25
Ionic TM5 K 326 5x64 G.H5 D 348 G.H5.13
Hydrophobic TM5 K 326 5x64 G.H5 D 348 G.H5.13
Hydrophobic ICL2 K 256 - G.hns1 R 31 G.hns1.02
Aromatic ICL2 F 253 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 343 G.H5.08
Hydrophobic TM5 L 323 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM3 I 248 3x58 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 248 3x58 G.H5 L 355 G.H5.20
Hydrophobic ICL2 V 252 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 F 253 - G.S3 F 196 G.S3.03
Van-der-waals ICL2 F 253 - G.S3 F 196 G.S3.03
Hydrophobic TM2 R 180 2x46 G.H5 Q 357 G.H5.22
Hydrophobic TM6 I 347 6x44 G.H5 E 359 G.H5.24
Aromatic TM2 R 180 2x46 G.H5 Y 358 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 Y 358 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 F 253 - G.S3 V 194 G.S3.01