κ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9UXX

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

May 27, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

40 interactions (Click to see)

LIGANDS

salvinorin A - Agonist pubchem gtoplig chembl_ligand chembl_ligand pubchem chembl_ligand pubchem chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), β-neoendorphin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), big dynorphin (Human), β-endorphin (Mouse), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 257 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 257 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 V 256 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 256 - G.H5 D 341 G.H5.13
Hydrophobic TM6 K 265 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 N 336 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 336 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM5 M 249 5x61 G.H5 L 353 G.H5.25
Polar ICL2 L 167 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 167 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 167 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 156 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 156 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 253 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 253 5x65 G.H5 L 348 G.H5.20
Ionic ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 257 - G.h4s6 E 318 G.h4s6.12
Polar H8 N 336 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 336 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL3 L 258 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 258 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 167 - G.S3 L 194 G.S3.01
Polar TM2 T 94 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 V 160 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 160 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 R 257 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 D 168 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 168 - G.hns1 R 32 G.hns1.03
Polar H8 N 336 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 336 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 258 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 163 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 163 - G.H5 I 344 G.H5.16
Hydrophobic TM6 I 272 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 258 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 258 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 T 94 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 164 - G.S3 L 194 G.S3.01
Hydrophobic H8 E 335 8x48 G.H5 L 353 G.H5.25
Van-der-waals ICL2 V 164 - G.s2s3 K 192 G.s2s3.01
Ionic ICL2 R 170 - G.H5 D 350 G.H5.22
Polar ICL2 R 170 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 170 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 170 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 258 - G.H5 V 342 G.H5.14
Van-der-waals TM3 V 160 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM4 T 171 4x38 G.hns1 R 32 G.hns1.03
Ionic ICL2 K 165 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 165 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 165 - G.s2s3 D 193 G.s2s3.02
Polar H8 R 339 8x52 G.H5 K 349 G.H5.21
Hydrophobic ICL3 L 258 - G.S6 Y 320 G.S6.02
Aromatic ICL3 R 257 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 257 - G.S6 Y 320 G.S6.02
Ionic TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 265 6x26 G.h4s6 E 318 G.h4s6.12
Polar H8 R 339 8x52 G.H5 F 354 G.H5.26
Van-der-waals H8 R 339 8x52 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 259 - G.H5 K 345 G.H5.17
Polar TM6 K 265 6x26 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 K 265 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 A 159 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 159 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 272 6x33 G.H5 L 353 G.H5.25
Hydrophobic H8 D 334 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 164 - G.s2s3 D 193 G.s2s3.02
Polar TM3 A 159 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 159 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 159 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 163 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 163 - G.H5 I 343 G.H5.15
Polar ICL2 R 170 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 170 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 170 - G.H5 C 351 G.H5.23
Polar H8 E 335 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 335 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 335 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL3 V 256 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 167 - G.H5 I 343 G.H5.15