ADGRD1 - G13

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9V0U

RESOLUTION

3.5 Å

REFERENCE

10.1016/J.BBRC.2025.152165

PUBLICATION DATE

July 30, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

No ligands

PHYSIOLOGICAL LIGANDS

dihydrotestosterone



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 M 660 3x57 G.H5 N 223 G.H5.19
Hydrophobic ICL2 F 665 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 F 665 - G.H5 I 219 G.H5.15
Hydrophobic TM6 V 764 6x44 G.H5 M 228 G.H5.24
Hydrophobic TM5 I 738 5x61 G.H5 M 228 G.H5.24
Van-der-waals TM5 I 738 5x61 G.H5 M 228 G.H5.24
Hydrophobic TM5 I 741 5x64 G.H5 L 220 G.H5.16
Hydrophobic TM5 V 737 5x60 G.H5 L 220 G.H5.16
Hydrophobic ICL2 V 664 - G.H5 K 216 G.H5.12
Hydrophobic TM5 I 738 5x61 G.H5 L 224 G.H5.20
Hydrophobic TM6 A 761 6x41 G.H5 M 228 G.H5.24
Hydrophobic TM3 V 661 3x58 G.H5 L 220 G.H5.16
Polar TM2 R 601 2x46 G.H5 Q 226 G.H5.22
Hydrophobic TM2 R 601 2x46 G.H5 Q 226 G.H5.22
Van-der-waals TM2 R 601 2x46 G.H5 Q 226 G.H5.22
Hydrophobic ICL2 F 665 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 F 665 - G.S1 V 34 G.S1.02
Aromatic ICL2 F 665 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 665 - G.H5 F 212 G.H5.08
Van-der-waals ICL2 F 665 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 665 - G.H5 K 216 G.H5.12
Hydrophobic ICL2 V 664 - G.H5 L 220 G.H5.16
Hydrophobic ICL2 F 665 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 F 665 - G.S3 V 79 G.S3.01
Hydrophobic TM5 I 741 5x64 G.H5 H 221 G.H5.17
Van-der-waals TM5 I 741 5x64 G.H5 H 221 G.H5.17
Van-der-waals ICL2 V 664 - G.H5 N 223 G.H5.19
Polar ICL1 N 599 - G.H5 Q 226 G.H5.22
Hydrophobic TM3 L 657 3x54 G.H5 L 227 G.H5.23
Hydrophobic ICL2 V 664 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 V 664 - G.H5 I 219 G.H5.15
Hydrophobic TM3 V 661 3x58 G.H5 L 227 G.H5.23
Polar TM3 I 662 3x59 G.H5 K 216 G.H5.12
Hydrophobic ICL2 F 665 - G.S3 F 81 G.S3.03
Hydrophobic TM3 M 660 3x57 G.H5 L 227 G.H5.23
Van-der-waals TM3 M 660 3x57 G.H5 L 227 G.H5.23
Hydrophobic ICL2 F 665 - G.H5 V 215 G.H5.11
Van-der-waals ICL2 F 665 - G.H5 V 215 G.H5.11