NPFF2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Feb. 4, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

GUB08248 - Agonist

PHYSIOLOGICAL LIGANDS

QRFP43 (43RFa) (Human), neuropeptide AF (Rat), neuropeptide AF (Human), RFRP-3 (Human), neuropeptide SF (Human), PrRP-31 (Human), neuropeptide AF (Mouse), neuropeptide FF (Human), RFRP-1 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic H8 N 337 8x47 G.H5 G 359 G.H5.24
Van-der-waals H8 N 337 8x47 G.H5 G 359 G.H5.24
Hydrophobic ICL2 P 150 - G.H5 I 351 G.H5.16
Van-der-waals ICL2 P 150 - G.H5 I 351 G.H5.16
Hydrophobic TM6 I 272 6x33 G.H5 F 361 G.H5.26
Van-der-waals TM6 I 272 6x33 G.H5 F 361 G.H5.26
Hydrophobic ICL2 F 151 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 F 151 - G.H5 I 350 G.H5.15
Polar TM3 D 142 3x49 G.H5 C 358 G.H5.23
Aromatic TM6 K 268 6x29 G.H5 F 361 G.H5.26
Hydrophobic TM6 K 268 6x29 G.H5 F 361 G.H5.26
Van-der-waals TM6 K 268 6x29 G.H5 F 361 G.H5.26
Hydrophobic ICL2 F 151 - G.H5 V 346 G.H5.11
Hydrophobic TM3 V 147 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 147 3x54 G.H5 L 355 G.H5.20
Polar ICL2 P 150 - G.H5 N 354 G.H5.19
Hydrophobic TM3 R 143 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM6 L 276 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 276 6x37 G.H5 L 360 G.H5.25
Polar H8 N 339 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 N 339 8x49 G.H5 R 356 G.H5.21
Hydrophobic ICL2 P 150 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 150 - G.H5 I 350 G.H5.15
Hydrophobic TM6 K 271 6x32 G.H5 F 361 G.H5.26
Hydrophobic ICL2 F 151 - G.S3 V 194 G.S3.01
Hydrophobic ICL2 F 151 - G.H5 T 347 G.H5.12
Van-der-waals ICL2 F 151 - G.H5 T 347 G.H5.12
Hydrophobic TM2 T 80 2x39 G.H5 C 358 G.H5.23
Hydrophobic TM6 I 272 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 I 272 6x33 G.H5 L 360 G.H5.25
Polar H8 N 339 8x49 G.H5 D 357 G.H5.22
Van-der-waals H8 N 339 8x49 G.H5 D 357 G.H5.22
Aromatic ICL2 F 151 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 F 151 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 F 151 - G.S1 H 34 G.S1.02
Polar TM3 C 146 3x53 G.H5 C 358 G.H5.23
Hydrophobic TM3 C 146 3x53 G.H5 C 358 G.H5.23
Van-der-waals TM3 C 146 3x53 G.H5 C 358 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 C 358 G.H5.23
Polar TM3 C 146 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 C 146 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 C 146 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM6 I 272 6x33 G.H5 L 355 G.H5.20
Hydrophobic TM6 V 265 6x26 G.H5 K 352 G.H5.17
Hydrophobic H8 N 339 8x49 G.H5 G 359 G.H5.24
Van-der-waals H8 N 339 8x49 G.H5 G 359 G.H5.24
Hydrophobic TM6 M 275 6x36 G.H5 L 360 G.H5.25
Van-der-waals TM6 M 275 6x36 G.H5 L 360 G.H5.25
Aromatic ICL2 F 151 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 151 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 F 151 - G.H5 F 343 G.H5.08
Polar H8 E 338 8x48 G.H5 F 361 G.H5.26
Hydrophobic H8 E 338 8x48 G.H5 F 361 G.H5.26
Ionic H8 E 338 8x48 G.H5 R 356 G.H5.21
Polar H8 E 338 8x48 G.H5 R 356 G.H5.21
Hydrophobic H8 E 338 8x48 G.H5 R 356 G.H5.21
Van-der-waals H8 E 338 8x48 G.H5 R 356 G.H5.21
Hydrophobic ICL2 P 150 - G.H5 T 347 G.H5.12