S1P2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.8 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM3 A 133 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 V 216 5x65 G.H5 I 344 G.H5.16
Polar TM7 R 291 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM7 R 291 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 R 291 7x56 G.H5 L 353 G.H5.25
Polar TM6 T 234 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 234 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 234 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 K 136 3x56 G.H5 I 343 G.H5.15
Hydrophobic TM6 Q 227 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 227 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 230 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 130 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 225 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 A 225 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL1 Y 69 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 Y 69 - G.H5 D 350 G.H5.22
Polar TM3 E 129 3x49 G.H5 C 351 G.H5.23
Ionic TM4 D 143 4x37 G.HN R 24 G.HN.48
Polar TM4 D 143 4x37 G.HN R 24 G.HN.48
Hydrophobic TM4 D 143 4x37 G.HN R 24 G.HN.48
Van-der-waals TM4 D 143 4x37 G.HN R 24 G.HN.48
Polar TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 Q 227 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 Q 227 6x29 G.H5 L 348 G.H5.20
Polar C-term D 294 - G.H5 K 349 G.H5.21
Van-der-waals C-term D 294 - G.H5 K 349 G.H5.21
Hydrophobic TM3 A 133 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM7 R 291 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 R 291 7x56 G.H5 G 352 G.H5.24
Polar TM4 C 146 4x40 G.HN R 24 G.HN.48
Hydrophobic TM4 C 146 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 C 146 4x40 G.HN R 24 G.HN.48
Van-der-waals C-term D 294 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 134 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 134 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 231 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 Q 227 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 227 6x29 G.H5 K 345 G.H5.17
Polar TM4 S 145 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 S 145 4x39 G.HN R 24 G.HN.48