S1P3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9W0O

RESOLUTION

3.0 Å

REFERENCE

10.1093/PROCEL/PWAF068

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 263 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 263 6x29 G.H5 K 345 G.H5.17
Polar ICL4 S 328 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 S 328 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 328 - G.H5 G 352 G.H5.24
Hydrophobic ICL2 M 169 - G.S3 L 194 G.S3.01
Hydrophobic TM2 M 100 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 100 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 T 165 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 M 166 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 M 166 3x54 G.H5 I 344 G.H5.16
Polar ICL2 P 171 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 171 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 171 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 V 248 5x65 G.H5 I 344 G.H5.16
Ionic TM6 R 263 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 263 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 171 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 171 - G.H5 I 343 G.H5.15
Polar TM3 K 168 3x56 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 171 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 P 171 - G.S1 V 34 G.S1.02
Polar ICL2 Y 172 - G.S1 K 35 G.S1.03
Hydrophobic ICL2 Y 172 - G.S1 K 35 G.S1.03
Van-der-waals ICL2 Y 172 - G.S1 K 35 G.S1.03
Hydrophobic ICL3 V 255 - G.H5 F 334 G.H5.06
Polar TM6 N 259 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 N 259 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 N 259 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 R 170 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 170 - G.hns1 R 32 G.hns1.03
Polar ICL2 Y 172 - G.h2s4 T 219 G.h2s4.05
Hydrophobic TM3 M 166 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 166 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 N 259 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 259 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 S 251 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 251 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 255 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 255 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 174 - G.HN E 28 G.HN.52
Hydrophobic ICL2 P 171 - G.hns1 R 32 G.hns1.03
Polar TM5 S 252 5x69 G.H5 D 341 G.H5.13
Van-der-waals ICL2 P 171 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 M 169 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 M 169 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 Y 172 - G.S1 E 33 G.S1.01
Hydrophobic TM5 S 251 5x68 G.H5 T 340 G.H5.12
Polar TM6 N 259 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 M 169 - G.H5 I 343 G.H5.15
Polar ICL2 Y 172 - G.h2s4 G 217 G.h2s4.03
Hydrophobic ICL2 Y 172 - G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 Y 172 - G.h2s4 G 217 G.h2s4.03
Hydrophobic TM6 L 267 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 267 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 263 6x29 G.H5 L 348 G.H5.20
Polar ICL2 Y 172 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 172 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 171 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 P 171 - G.S1 E 33 G.S1.01
Polar TM6 R 263 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM3 M 166 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL4 S 328 - G.H5 F 354 G.H5.26
Hydrophobic TM2 M 100 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 100 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 162 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 170 - G.H5 I 343 G.H5.15
Ionic TM5 K 254 5x71 G.H5 D 337 G.H5.09
Polar TM5 K 254 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 254 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 254 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 S 251 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 251 5x68 G.H5 D 341 G.H5.13
Van-der-waals H8 E 330 8x49 G.H5 F 354 G.H5.26
Hydrophobic ICL3 V 255 - G.S6 Y 320 G.S6.02
Aromatic TM6 R 263 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 263 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 263 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 267 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 174 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 162 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 162 3x50 G.H5 L 353 G.H5.25
Polar TM3 T 165 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 T 165 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 T 165 3x53 G.H5 N 347 G.H5.19