TAS2R14 - Gi1

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

April 22, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

TANGERETIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM5 H 208 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 M 212 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 212 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 111 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 N 113 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 N 113 - G.H5 I 344 G.H5.16
Ionic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Polar TM5 K 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 211 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 211 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 K 110 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 111 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 F 106 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 N 347 G.H5.19
Polar TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 V 216 - G.S6 Y 320 G.S6.02
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Ionic TM3 K 110 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 350 G.H5.22
Hydrophobic H8 N 284 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 284 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 111 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 111 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 H 208 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 216 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 V 216 - G.H5 F 334 G.H5.06
Hydrophobic H8 K 285 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 285 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 M 212 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 M 212 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 M 205 5x65 G.H5 I 344 G.H5.16
Aromatic ICL2 W 124 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 124 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 124 - G.hns1 R 32 G.hns1.03
Ionic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 341 G.H5.13
Polar H8 K 285 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 K 285 8x48 G.H5 G 352 G.H5.24
Polar H8 R 288 8x51 G.H5 L 353 G.H5.25
Van-der-waals H8 R 288 8x51 G.H5 L 353 G.H5.25
Polar TM5 K 211 5x71 G.H5 T 340 G.H5.12
Hydrophobic H8 R 288 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 R 288 8x51 G.H5 F 354 G.H5.26
Hydrophobic TM5 M 212 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM5 M 205 5x65 G.H5 L 348 G.H5.20
Polar TM3 K 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 347 G.H5.19