UL33 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Human cytomegalovirus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Feb. 25, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

No ligands

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 T 137 - G.H5 I 383 G.H5.15
Hydrophobic H8 G 310 8x47 G.H5 L 394 G.H5.26
Van-der-waals H8 G 310 8x47 G.H5 L 394 G.H5.26
Polar ICL2 R 136 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 136 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 136 - G.S1 H 41 G.S1.02
Hydrophobic TM6 V 246 6x37 G.H5 Y 391 G.H5.23
Polar ICL2 R 136 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 R 136 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 136 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 Y 138 - G.H5 M 386 G.H5.18
Hydrophobic TM3 R 131 3x52 G.H5 H 387 G.H5.19
Van-der-waals TM3 R 131 3x52 G.H5 H 387 G.H5.19
Hydrophobic H8 D 312 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 D 312 8x49 G.H5 L 393 G.H5.25
Polar ICL2 K 135 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 135 - G.H5 H 387 G.H5.19
Polar TM6 T 244 6x35 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 244 6x35 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 244 6x35 G.H5 E 392 G.H5.24
Polar H8 H 311 8x48 G.H5 L 393 G.H5.25
Hydrophobic H8 H 311 8x48 G.H5 L 393 G.H5.25
Van-der-waals H8 H 311 8x48 G.H5 L 393 G.H5.25
Polar H8 D 312 8x49 G.H5 L 394 G.H5.26
Hydrophobic H8 D 312 8x49 G.H5 L 394 G.H5.26
Van-der-waals H8 D 312 8x49 G.H5 L 394 G.H5.26
Hydrophobic TM6 F 245 6x36 G.H5 Y 391 G.H5.23
Van-der-waals TM6 F 245 6x36 G.H5 Y 391 G.H5.23
Hydrophobic TM2 P 68 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 68 2x39 G.H5 Y 391 G.H5.23
Ionic TM3 R 129 3x50 G.H5 E 392 G.H5.24
Hydrophobic TM6 F 245 6x36 G.H5 L 394 G.H5.26
Polar TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM2 M 72 2x43 G.H5 L 394 G.H5.26
Van-der-waals TM2 M 72 2x43 G.H5 L 394 G.H5.26
Hydrophobic ICL2 T 137 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 T 137 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 136 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 136 - G.S3 V 217 G.S3.01
Polar H8 H 311 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 H 311 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 H 311 8x48 G.H5 E 392 G.H5.24
Polar H8 H 311 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 H 311 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 H 311 8x48 G.H5 L 394 G.H5.26
Polar ICL2 R 136 - G.S3 N 218 G.S3.02
Van-der-waals ICL2 R 136 - G.S3 N 218 G.S3.02
Polar TM3 D 128 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 128 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 128 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 T 137 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 T 137 - G.S1 H 41 G.S1.02
Hydrophobic H8 F 313 8x50 G.H5 L 394 G.H5.26
Hydrophobic ICL2 K 135 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 K 135 - G.H5 I 383 G.H5.15
Polar TM3 V 132 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 132 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 132 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 132 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 V 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 132 3x53 G.H5 L 388 G.H5.20
Polar TM3 I 125 3x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL1 L 63 - G.H5 L 393 G.H5.25
Van-der-waals ICL1 L 63 - G.H5 L 393 G.H5.25
Polar ICL2 R 136 - G.s2s3 K 216 G.s2s3.02