Refined structure (7LD4) of Gi2 - A1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 210 from structure (59.2%), 145 from model (40.8%)
Residue sidechains - 206 from structure (58.0%), 149 from model (42.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 V G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 AF2 AF2
G.HN 7 A G.HN.31 AF2 AF2
G.HN 8 E G.HN.32 AF2 AF2
G.HN 9 D G.HN.33 AF2 AF2
G.HN 10 K G.HN.34 AF2 AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 A G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 R H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 R H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 M H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 K H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 N H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 Q H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 A H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 P H.hahb.09 AF2 AF2
H.HB 99 S H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 A H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 S H.HB.13 AF2 AF2
H.HB 112 C H.HB.14 AF2 AF2
H.hbhc 113 T H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 Q H.hbhc.11 AF2 AF2
H.hbhc 118 G H.hbhc.12 AF2 AF2
H.hbhc 119 V H.hbhc.13 AF2 AF2
H.hbhc 120 L H.hbhc.14 AF2 AF2
H.hbhc 121 P H.hbhc.15 AF2 AF2
H.HC 122 D H.HC.01 AF2 AF2
H.HC 123 D H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 S H.HC.04 AF2 AF2
H.HC 126 G H.HC.05 AF2 AF2
H.HC 127 V H.HC.06 AF2 AF2
H.HC 128 I H.HC.07 AF2 AF2
H.HC 129 R H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 A H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 H H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 V H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 A H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 G H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 A H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 N H.HE.07 AF2 AF2
H.HE 159 D H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 E H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 A H.HE.13 AF2 AF2
H.hehf 165 Q H.hehf.01 AF2 AF2
H.hehf 166 S H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 I H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 Q H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 V H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 AF2 AF2
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 D G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 K G.S3.04 Structure Structure
G.S3 199 M G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure AF2
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure Structure
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 G G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure Structure
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 A G.s4h3.03 Structure Structure
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 Structure Structure
G.s4h3 233 L G.s4h3.06 Structure Structure
G.s4h3 234 V G.s4h3.07 Structure Structure
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 A G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 E G.s4h3.13 AF2 AF2
G.s4h3 241 M G.s4h3.14 Structure Structure
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure AF2
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 M G.H3.06 Structure Structure
G.H3 249 K G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 W G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 T G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 E G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 T G.HG.09 Structure Structure
G.HG 281 H G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 A G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 K G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 D G.H4.04 Structure Structure
G.H4 299 E G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 S G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 S G.H4.13 Structure Structure
G.H4 307 K G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 D G.H4.17 Structure Structure
G.h4s6 311 L G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 K G.h4s6.03 Structure Structure
G.h4s6 314 R G.h4s6.04 Structure Structure
G.h4s6 315 K G.h4s6.08 Structure Structure
G.h4s6 316 D G.h4s6.09 Structure Structure
G.h4s6 317 T G.h4s6.10 Structure Structure
G.h4s6 318 K G.h4s6.11 Structure Structure
G.h4s6 319 E G.h4s6.12 Structure Structure
G.S6 320 I G.S6.01 Structure Structure
G.S6 321 Y G.S6.02 Structure Structure
G.S6 322 T G.S6.03 Structure Structure
G.S6 323 H G.S6.04 Structure Structure
G.S6 324 F G.S6.05 Structure Structure
G.s6h5 325 T G.s6h5.01 Structure Structure
G.s6h5 326 C G.s6h5.02 Structure Structure
G.s6h5 327 A G.s6h5.03 Structure AF2
G.s6h5 328 T G.s6h5.04 Structure Structure
G.s6h5 329 D G.s6h5.05 Structure Structure
G.H5 330 T G.H5.01 Structure Structure
G.H5 331 K G.H5.02 Structure Structure
G.H5 332 N G.H5.03 Structure Structure
G.H5 333 V G.H5.04 Structure Structure
G.H5 334 Q G.H5.05 Structure Structure
G.H5 335 F G.H5.06 Structure Structure
G.H5 336 V G.H5.07 Structure Structure
G.H5 337 F G.H5.08 Structure Structure
G.H5 338 D G.H5.09 Structure Structure
G.H5 339 A G.H5.10 Structure Structure
G.H5 340 V G.H5.11 Structure Structure
G.H5 341 T G.H5.12 Structure Structure
G.H5 342 D G.H5.13 Structure Structure
G.H5 343 V G.H5.14 Structure Structure
G.H5 344 I G.H5.15 Structure Structure
G.H5 345 I G.H5.16 Structure Structure
G.H5 346 K G.H5.17 Structure Structure
G.H5 347 N G.H5.18 Structure Structure
G.H5 348 N G.H5.19 Structure Structure
G.H5 349 L G.H5.20 Structure Structure
G.H5 350 K G.H5.21 Structure Structure
G.H5 351 D G.H5.22 Structure Structure
G.H5 352 C G.H5.23 Structure Structure
G.H5 353 G G.H5.24 Structure Structure
G.H5 354 L G.H5.25 Structure Structure
G.H5 355 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 286 from structure (88.3%), 38 from model (11.7%)
Residue sidechains - 286 from structure (88.3%), 38 from model (11.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 I - AF2 AF2
TM1 6 S 1.29x29 Structure Structure
TM1 7 A 1.30x30 Structure Structure
TM1 8 F 1.31x31 Structure Structure
TM1 9 Q 1.32x32 Structure Structure
TM1 10 A 1.33x33 Structure Structure
TM1 11 A 1.34x34 Structure Structure
TM1 12 Y 1.35x35 Structure Structure
TM1 13 I 1.36x36 Structure Structure
TM1 14 G 1.37x37 Structure Structure
TM1 15 I 1.38x38 Structure Structure
TM1 16 E 1.39x39 Structure Structure
TM1 17 V 1.40x40 Structure Structure
TM1 18 L 1.41x41 Structure Structure
TM1 19 I 1.42x42 Structure Structure
TM1 20 A 1.43x43 Structure Structure
TM1 21 L 1.44x44 Structure Structure
TM1 22 V 1.45x45 Structure Structure
TM1 23 S 1.46x46 Structure Structure
TM1 24 V 1.47x47 Structure Structure
TM1 25 P 1.48x48 Structure Structure
TM1 26 G 1.49x49 Structure Structure
TM1 27 N 1.50x50 Structure Structure
TM1 28 V 1.51x51 Structure Structure
TM1 29 L 1.52x52 Structure Structure
TM1 30 V 1.53x53 Structure Structure
TM1 31 I 1.54x54 Structure Structure
TM1 32 W 1.55x55 Structure Structure
TM1 33 A 1.56x56 Structure Structure
TM1 34 V 1.57x57 Structure Structure
TM1 35 K 1.58x58 Structure Structure
TM1 36 V 1.59x59 Structure Structure
TM1 37 N 1.60x60 Structure Structure
ICL1 38 Q 12.48x48 Structure Structure
ICL1 39 A 12.49x49 Structure Structure
ICL1 40 L 12.50x50 Structure Structure
ICL1 41 R 12.51x51 Structure Structure
TM2 42 D 2.37x37 Structure Structure
TM2 43 A 2.38x38 Structure Structure
TM2 44 T 2.39x39 Structure Structure
TM2 45 F 2.40x40 Structure Structure
TM2 46 C 2.41x41 Structure Structure
TM2 47 F 2.42x42 Structure Structure
TM2 48 I 2.43x43 Structure Structure
TM2 49 V 2.44x44 Structure Structure
TM2 50 S 2.45x45 Structure Structure
TM2 51 L 2.46x46 Structure Structure
TM2 52 A 2.47x47 Structure Structure
TM2 53 V 2.48x48 Structure Structure
TM2 54 A 2.49x49 Structure Structure
TM2 55 D 2.50x50 Structure Structure
TM2 56 V 2.51x51 Structure Structure
TM2 57 A 2.52x52 Structure Structure
TM2 58 V 2.53x53 Structure Structure
TM2 59 G 2.54x54 Structure Structure
TM2 60 A 2.55x55 Structure Structure
TM2 61 L 2.56x551 Structure Structure
TM2 62 V 2.57x56 Structure Structure
TM2 63 I 2.58x57 Structure Structure
TM2 64 P 2.59x58 Structure Structure
TM2 65 L 2.60x59 Structure Structure
TM2 66 A 2.61x60 Structure Structure
TM2 67 I 2.62x61 Structure Structure
TM2 68 L 2.63x62 Structure Structure
TM2 69 I 2.64x63 Structure Structure
TM2 70 N 2.65x64 Structure Structure
TM2 71 I 2.66x65 Structure Structure
TM2 72 G 2.67x66 Structure Structure
ECL1 73 P 23.50x50 Structure Structure
ECL1 74 Q 23.51x51 Structure Structure
ECL1 75 T 23.52x52 Structure Structure
TM3 76 Y 3.21x21 Structure Structure
TM3 77 F 3.22x22 Structure Structure
TM3 78 H 3.23x23 Structure Structure
TM3 79 T 3.24x24 Structure Structure
TM3 80 C 3.25x25 Structure Structure
TM3 81 L 3.26x26 Structure Structure
TM3 82 M 3.27x27 Structure Structure
TM3 83 V 3.28x28 Structure Structure
TM3 84 A 3.29x29 Structure Structure
TM3 85 C 3.30x30 Structure Structure
TM3 86 P 3.31x31 Structure Structure
TM3 87 V 3.32x32 Structure Structure
TM3 88 L 3.33x33 Structure Structure
TM3 89 I 3.34x34 Structure Structure
TM3 90 L 3.35x35 Structure Structure
TM3 91 T 3.36x36 Structure Structure
TM3 92 Q 3.37x37 Structure Structure
TM3 93 S 3.38x38 Structure Structure
TM3 94 S 3.39x39 Structure Structure
TM3 95 I 3.40x40 Structure Structure
TM3 96 L 3.41x41 Structure Structure
TM3 97 A 3.42x42 Structure Structure
TM3 98 L 3.43x43 Structure Structure
TM3 99 L 3.44x44 Structure Structure
TM3 100 A 3.45x45 Structure Structure
TM3 101 I 3.46x46 Structure Structure
TM3 102 A 3.47x47 Structure Structure
TM3 103 V 3.48x48 Structure Structure
TM3 104 D 3.49x49 Structure Structure
TM3 105 R 3.50x50 Structure Structure
TM3 106 Y 3.51x51 Structure Structure
TM3 107 L 3.52x52 Structure Structure
TM3 108 R 3.53x53 Structure Structure
TM3 109 V 3.54x54 Structure Structure
TM3 110 K 3.55x55 Structure Structure
TM3 111 I 3.56x56 Structure Structure
ICL2 112 P 34.50x50 Structure Structure
ICL2 113 L 34.51x51 Structure Structure
ICL2 114 R 34.52x52 Structure Structure
ICL2 115 Y 34.53x53 Structure Structure
ICL2 116 K 34.54x54 Structure Structure
ICL2 117 M 34.55x55 Structure Structure
ICL2 118 V 34.56x56 Structure Structure
ICL2 119 V 34.57x57 Structure Structure
TM4 120 T 4.38x38 Structure Structure
TM4 121 P 4.39x39 Structure Structure
TM4 122 R 4.40x40 Structure Structure
TM4 123 R 4.41x41 Structure Structure
TM4 124 A 4.42x42 Structure Structure
TM4 125 A 4.43x43 Structure Structure
TM4 126 V 4.44x44 Structure Structure
TM4 127 A 4.45x45 Structure Structure
TM4 128 I 4.46x46 Structure Structure
TM4 129 A 4.47x47 Structure Structure
TM4 130 G 4.48x48 Structure Structure
TM4 131 C 4.49x49 Structure Structure
TM4 132 W 4.50x50 Structure Structure
TM4 133 I 4.51x51 Structure Structure
TM4 134 L 4.52x52 Structure Structure
TM4 135 S 4.53x53 Structure Structure
TM4 136 F 4.54x54 Structure Structure
TM4 137 V 4.55x55 Structure Structure
TM4 138 V 4.56x56 Structure Structure
TM4 139 G 4.57x57 Structure Structure
TM4 140 L 4.58x58 Structure Structure
TM4 141 T 4.59x59 Structure Structure
TM4 142 P 4.60x60 Structure Structure
TM4 143 M 4.61x61 Structure Structure
TM4 144 F 4.62x62 Structure Structure
TM4 145 G 4.63x63 Structure Structure
ECL2 146 W - Structure Structure
ECL2 147 N - Structure Structure
ECL2 148 N - Structure Structure
ECL2 149 L - Structure Structure
ECL2 150 S - Structure Structure
ECL2 151 A - Structure Structure
ECL2 152 V - Structure Structure
ECL2 153 E - Structure Structure
ECL2 154 R - Structure Structure
ECL2 155 A - Structure Structure
ECL2 156 W - Structure Structure
ECL2 157 A - Structure Structure
ECL2 158 A - Structure Structure
ECL2 159 N - Structure Structure
ECL2 160 G - Structure Structure
ECL2 161 S - Structure Structure
ECL2 162 M - Structure Structure
ECL2 163 G - Structure Structure
ECL2 164 E - Structure Structure
ECL2 165 P - Structure Structure
ECL2 166 V - Structure Structure
ECL2 167 I - Structure Structure
ECL2 168 K - Structure Structure
ECL2 169 C 45.50x50 Structure Structure
ECL2 170 E 45.51x51 Structure Structure
ECL2 171 F 45.52x52 Structure Structure
ECL2 172 E - Structure Structure
ECL2 173 K - Structure Structure
ECL2 174 V - Structure Structure
ECL2 175 I - Structure Structure
TM5 176 S 5.34x36 Structure Structure
TM5 177 M 5.35x37 Structure Structure
TM5 178 E 5.36x38 Structure Structure
TM5 179 Y 5.37x39 Structure Structure
TM5 180 M 5.38x40 Structure Structure
TM5 181 V 5.39x41 Structure Structure
TM5 182 Y 5.40x411 Structure Structure
TM5 183 F 5.41x42 Structure Structure
TM5 184 N 5.42x43 Structure Structure
TM5 185 F 5.43x44 Structure Structure
TM5 186 F 5.44x45 Structure Structure
TM5 187 V 5.45x46 Structure Structure
TM5 188 W 5.46x461 Structure Structure
TM5 189 V 5.47x47 Structure Structure
TM5 190 L 5.48x48 Structure Structure
TM5 191 P 5.49x49 Structure Structure
TM5 192 P 5.50x50 Structure Structure
TM5 193 L 5.51x51 Structure Structure
TM5 194 L 5.52x52 Structure Structure
TM5 195 L 5.53x53 Structure Structure
TM5 196 M 5.54x54 Structure Structure
TM5 197 V 5.55x55 Structure Structure
TM5 198 L 5.56x56 Structure Structure
TM5 199 I 5.57x57 Structure Structure
TM5 200 Y 5.58x58 Structure Structure
TM5 201 L 5.59x59 Structure Structure
TM5 202 E 5.60x60 Structure Structure
TM5 203 V 5.61x61 Structure Structure
TM5 204 F 5.62x62 Structure Structure
TM5 205 Y 5.63x63 Structure Structure
TM5 206 L 5.64x64 Structure Structure
TM5 207 I 5.65x65 Structure Structure
TM5 208 R 5.66x66 Structure Structure
TM5 209 K 5.67x67 Structure Structure
TM5 210 Q 5.68x68 Structure Structure
TM5 211 L 5.69x69 Structure Structure
TM5 212 N 5.70x70 Structure Structure
TM5 213 K 5.71x71 Structure Structure
TM5 214 K 5.72x72 AF2 AF2
TM5 215 V 5.73x73 AF2 AF2
ICL3 216 S - AF2 AF2
ICL3 217 A - AF2 AF2
ICL3 218 S - AF2 AF2
ICL3 219 S - AF2 AF2
ICL3 220 G - AF2 AF2
TM6 221 D 6.22x22 AF2 AF2
TM6 222 P 6.23x23 AF2 AF2
TM6 223 Q 6.24x24 AF2 AF2
TM6 224 K 6.25x25 Structure Structure
TM6 225 Y 6.26x26 Structure Structure
TM6 226 Y 6.27x27 Structure Structure
TM6 227 G 6.28x28 Structure Structure
TM6 228 K 6.29x29 Structure Structure
TM6 229 E 6.30x30 Structure Structure
TM6 230 L 6.31x31 Structure Structure
TM6 231 K 6.32x32 Structure Structure
TM6 232 I 6.33x33 Structure Structure
TM6 233 A 6.34x34 Structure Structure
TM6 234 K 6.35x35 Structure Structure
TM6 235 S 6.36x36 Structure Structure
TM6 236 L 6.37x37 Structure Structure
TM6 237 A 6.38x38 Structure Structure
TM6 238 L 6.39x39 Structure Structure
TM6 239 I 6.40x40 Structure Structure
TM6 240 L 6.41x41 Structure Structure
TM6 241 F 6.42x42 Structure Structure
TM6 242 L 6.43x43 Structure Structure
TM6 243 F 6.44x44 Structure Structure
TM6 244 A 6.45x45 Structure Structure
TM6 245 L 6.46x46 Structure Structure
TM6 246 S 6.47x47 Structure Structure
TM6 247 W 6.48x48 Structure Structure
TM6 248 L 6.49x49 Structure Structure
TM6 249 P 6.50x50 Structure Structure
TM6 250 L 6.51x51 Structure Structure
TM6 251 H 6.52x52 Structure Structure
TM6 252 I 6.53x53 Structure Structure
TM6 253 L 6.54x54 Structure Structure
TM6 254 N 6.55x55 Structure Structure
TM6 255 C 6.56x56 Structure Structure
TM6 256 I 6.57x57 Structure Structure
TM6 257 T 6.58x58 Structure Structure
TM6 258 L 6.59x59 Structure Structure
TM6 259 F 6.60x60 Structure Structure
TM6 260 C 6.61x61 Structure Structure
ECL3 261 P - Structure Structure
ECL3 262 S - Structure Structure
ECL3 263 C - Structure Structure
ECL3 264 H - Structure Structure
ECL3 265 K - Structure Structure
TM7 266 P 7.31x30 Structure Structure
TM7 267 S 7.32x31 Structure Structure
TM7 268 I 7.33x32 Structure Structure
TM7 269 L 7.34x33 Structure Structure
TM7 270 T 7.35x34 Structure Structure
TM7 271 Y 7.36x35 Structure Structure
TM7 272 I 7.37x36 Structure Structure
TM7 273 A 7.38x37 Structure Structure
TM7 274 I 7.39x38 Structure Structure
TM7 275 F 7.40x39 Structure Structure
TM7 276 L 7.41x40 Structure Structure
TM7 277 T 7.42x41 Structure Structure
TM7 278 H 7.43x42 Structure Structure
TM7 279 G 7.44x43 Structure Structure
TM7 280 N 7.45x45 Structure Structure
TM7 281 S 7.46x46 Structure Structure
TM7 282 A 7.47x47 Structure Structure
TM7 283 M 7.48x48 Structure Structure
TM7 284 N 7.49x49 Structure Structure
TM7 285 P 7.50x50 Structure Structure
TM7 286 I 7.51x51 Structure Structure
TM7 287 V 7.52x52 Structure Structure
TM7 288 Y 7.53x53 Structure Structure
TM7 289 A 7.54x54 Structure Structure
TM7 290 F 7.55x55 Structure Structure
TM7 291 R 7.56x56 Structure Structure
H8 292 I 8.47x47 Structure Structure
H8 293 Q 8.48x48 Structure Structure
H8 294 K 8.49x49 Structure Structure
H8 295 F 8.50x50 Structure Structure
H8 296 R 8.51x51 Structure Structure
H8 297 V 8.52x52 Structure Structure
H8 298 T 8.53x53 Structure Structure
H8 299 F 8.54x54 Structure Structure
H8 300 L 8.55x55 Structure Structure
H8 301 K 8.56x56 Structure Structure
H8 302 I 8.57x57 AF2 AF2
H8 303 W 8.58x58 AF2 AF2
H8 304 N 8.59x59 AF2 AF2
H8 305 D 8.60x60 AF2 AF2
H8 306 H 8.61x61 AF2 AF2
H8 307 F 8.62x62 AF2 AF2
H8 308 R 8.63x63 AF2 AF2
H8 309 C 8.64x64 AF2 AF2
H8 310 Q 8.65x65 AF2 AF2
H8 311 P 8.66x66 AF2 AF2
H8 312 A 8.67x67 AF2 AF2
H8 313 P 8.68x68 AF2 AF2
H8 314 P 8.69x69 AF2 AF2
C-term 315 I - AF2 AF2
C-term 316 D - AF2 AF2
C-term 317 E - AF2 AF2
C-term 318 D - AF2 AF2
C-term 319 L - AF2 AF2
C-term 320 P - AF2 AF2
C-term 321 E - AF2 AF2
C-term 322 E - AF2 AF2
C-term 323 R - AF2 AF2
C-term 324 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 113 34x51 G.S3 L 195 G.S3.01
Hydrophobic H8 K 294 8x49 G.H5 D 351 G.H5.22
Hydrophobic ICL2 L 113 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM3 V 109 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 109 3x54 G.H5 L 349 G.H5.20
Polar ICL2 P 112 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 112 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 211 5x69 G.H5 F 355 G.H5.26
Hydrophobic TM5 Q 210 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 210 5x68 G.H5 I 345 G.H5.16
Hydrophobic H8 I 292 8x47 G.H5 C 352 G.H5.23
Van-der-waals H8 I 292 8x47 G.H5 C 352 G.H5.23
Hydrophobic TM5 I 207 5x65 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 113 34x51 G.H5 I 344 G.H5.15
Polar TM3 R 108 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 108 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 R 108 3x53 G.H5 N 348 G.H5.19
Polar TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 210 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL2 P 112 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 112 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL3 S 219 - G.H4 Q 305 G.H4.12
Hydrophobic TM6 L 236 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 211 5x69 G.H5 K 346 G.H5.17
Ionic TM5 K 214 5x72 G.h4s6 E 319 G.h4s6.12
Polar TM5 K 214 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 K 214 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 K 214 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 I 292 8x47 G.H5 D 351 G.H5.22
Van-der-waals H8 I 292 8x47 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 108 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 108 3x53 G.H5 C 352 G.H5.23
Polar TM3 R 105 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 105 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 105 3x50 G.H5 C 352 G.H5.23
Polar TM6 K 231 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 231 6x32 G.H5 L 354 G.H5.25
Polar TM6 Y 225 6x26 G.H5 K 346 G.H5.17
Hydrophobic TM5 I 207 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 I 232 6x33 G.H5 F 355 G.H5.26
Ionic TM5 K 213 5x71 G.H5 D 342 G.H5.13
Polar TM5 K 213 5x71 G.H5 D 342 G.H5.13
Ionic TM3 R 108 3x53 G.H5 D 351 G.H5.22
Polar TM3 R 108 3x53 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 108 3x53 G.H5 D 351 G.H5.22
Hydrophobic ICL2 P 112 34x50 G.H5 I 344 G.H5.15
Ionic TM5 K 213 5x71 G.H5 D 338 G.H5.09
Hydrophobic H8 I 292 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM6 I 232 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 232 6x33 G.H5 L 354 G.H5.25
Aromatic TM6 K 228 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 228 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 228 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM7 R 291 7x56 G.H5 G 353 G.H5.24