Biased Signaling Atlas

Refined structure (7X9A) of G_i1 - Y₁ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (60.7%), 139 from model (39.3%)
Residue sidechains - 182 from structure (51.4%), 172 from model (48.6%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	AF2	AF2
G.HN	5	L	G.HN.11	AF2	AF2
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	AF2
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	AF2
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	AF2
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	AF2
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	AF2
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	AF2
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	AF2
G.H1	47	S	G.H1.02	Structure	AF2
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	AF2
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	AF2
G.H1	54	K	G.H1.09	Structure	AF2
G.H1	55	I	G.H1.10	Structure	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	AF2
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	AF2
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	AF2
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	AF2
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	AF2
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	AF2	AF2
G.s4h3	233	V	G.s4h3.07	AF2	AF2
G.s4h3	234	L	G.s4h3.08	AF2	AF2
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	Structure	Structure
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	AF2
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	Structure
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	AF2
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	AF2
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	AF2
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	AF2
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	AF2
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	AF2
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	AF2
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	AF2
G.h4s6	318	E	G.h4s6.12	Structure	AF2
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	AF2
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	AF2
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	AF2
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 309 from structure (89.6%), 36 from model (10.4%)
Residue sidechains - 286 from structure (82.9%), 59 from model (17.1%)

Showing 1 to 345 of 345 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	N	-	AF2	AF2
N-term	3	S	-	AF2	AF2
N-term	4	T	-	AF2	AF2
N-term	5	L	-	AF2	AF2
N-term	6	F	-	AF2	AF2
N-term	7	S	-	AF2	AF2
N-term	8	Q	-	AF2	AF2
N-term	9	V	-	AF2	AF2
N-term	10	E	-	AF2	AF2
N-term	11	N	-	AF2	AF2
N-term	12	H	-	AF2	AF2
N-term	13	S	-	AF2	AF2
N-term	14	V	-	AF2	AF2
N-term	15	H	-	AF2	AF2
N-term	16	S	-	AF2	AF2
N-term	17	N	-	AF2	AF2
N-term	18	F	-	AF2	AF2
N-term	19	S	-	AF2	AF2
N-term	20	E	-	AF2	AF2
N-term	21	K	-	AF2	AF2
N-term	22	N	-	AF2	AF2
N-term	23	A	-	AF2	AF2
N-term	24	Q	-	AF2	AF2
N-term	25	L	-	AF2	AF2
N-term	26	L	-	AF2	AF2
N-term	27	A	-	AF2	AF2
N-term	28	F	-	Structure	Structure
N-term	29	E	-	Structure	Structure
N-term	30	N	-	Structure	Structure
N-term	31	D	-	Structure	Structure
N-term	32	D	-	Structure	Structure
N-term	33	C	-	Structure	Structure
N-term	34	H	-	Structure	AF2
N-term	35	L	-	Structure	Structure
TM1	36	P	1.28x28	Structure	Structure
TM1	37	L	1.29x29	Structure	Structure
TM1	38	A	1.30x30	Structure	Structure
TM1	39	M	1.31x31	Structure	Structure
TM1	40	I	1.32x32	Structure	Structure
TM1	41	F	1.33x33	Structure	Structure
TM1	42	T	1.34x34	Structure	Structure
TM1	43	L	1.35x35	Structure	Structure
TM1	44	A	1.36x36	Structure	Structure
TM1	45	L	1.37x37	Structure	Structure
TM1	46	A	1.38x38	Structure	Structure
TM1	47	Y	1.39x39	Structure	Structure
TM1	48	G	1.40x40	Structure	Structure
TM1	49	A	1.41x41	Structure	Structure
TM1	50	V	1.42x42	Structure	Structure
TM1	51	I	1.43x43	Structure	Structure
TM1	52	I	1.44x44	Structure	Structure
TM1	53	L	1.45x45	Structure	Structure
TM1	54	G	1.46x46	Structure	Structure
TM1	55	V	1.47x47	Structure	Structure
TM1	56	S	1.48x48	Structure	Structure
TM1	57	G	1.49x49	Structure	Structure
TM1	58	N	1.50x50	Structure	Structure
TM1	59	L	1.51x51	Structure	Structure
TM1	60	A	1.52x52	Structure	Structure
TM1	61	L	1.53x53	Structure	Structure
TM1	62	I	1.54x54	Structure	Structure
TM1	63	I	1.55x55	Structure	Structure
TM1	64	I	1.56x56	Structure	Structure
TM1	65	I	1.57x57	Structure	Structure
TM1	66	L	1.58x58	Structure	Structure
TM1	67	K	1.59x59	Structure	Structure
TM1	68	Q	1.60x60	Structure	Structure
ICL1	69	K	12.48x48	Structure	Structure
ICL1	70	E	12.49x49	Structure	Structure
ICL1	71	M	12.50x50	Structure	AF2
ICL1	72	R	12.51x51	Structure	AF2
TM2	73	N	2.37x37	Structure	Structure
TM2	74	V	2.38x38	Structure	Structure
TM2	75	T	2.39x39	Structure	Structure
TM2	76	N	2.40x40	Structure	Structure
TM2	77	I	2.41x41	Structure	Structure
TM2	78	L	2.42x42	Structure	Structure
TM2	79	I	2.43x43	Structure	Structure
TM2	80	V	2.44x44	Structure	Structure
TM2	81	N	2.45x45	Structure	Structure
TM2	82	L	2.46x46	Structure	Structure
TM2	83	S	2.47x47	Structure	Structure
TM2	84	F	2.48x48	Structure	Structure
TM2	85	S	2.49x49	Structure	Structure
TM2	86	D	2.50x50	Structure	Structure
TM2	87	L	2.51x51	Structure	Structure
TM2	88	L	2.52x52	Structure	Structure
TM2	89	V	2.53x53	Structure	Structure
TM2	90	A	2.54x54	Structure	Structure
TM2	91	I	2.55x55	Structure	Structure
TM2	92	M	2.56x551	Structure	Structure
TM2	93	C	2.57x56	Structure	Structure
TM2	94	L	2.58x57	Structure	Structure
TM2	95	P	2.59x58	Structure	Structure
TM2	96	F	2.60x59	Structure	Structure
TM2	97	T	2.61x60	Structure	Structure
TM2	98	F	2.62x61	Structure	Structure
TM2	99	V	2.63x62	Structure	Structure
TM2	100	Y	2.64x63	Structure	Structure
TM2	101	T	2.65x64	Structure	Structure
TM2	102	L	2.66x65	Structure	Structure
TM2	103	M	2.67x66	Structure	Structure
TM2	104	D	2.68x67	Structure	Structure
ECL1	105	H	23.49x49	Structure	Structure
ECL1	106	W	23.50x50	Structure	Structure
ECL1	107	V	23.51x51	Structure	Structure
ECL1	108	F	23.52x52	Structure	Structure
TM3	109	G	3.21x21	Structure	Structure
TM3	110	E	3.22x22	Structure	AF2
TM3	111	A	3.23x23	Structure	Structure
TM3	112	M	3.24x24	Structure	Structure
TM3	113	C	3.25x25	Structure	Structure
TM3	114	K	3.26x26	Structure	Structure
TM3	115	L	3.27x27	Structure	Structure
TM3	116	N	3.28x28	Structure	Structure
TM3	117	P	3.29x29	Structure	Structure
TM3	118	F	3.30x30	Structure	Structure
TM3	119	V	3.31x31	Structure	Structure
TM3	120	Q	3.32x32	Structure	Structure
TM3	121	C	3.33x33	Structure	Structure
TM3	122	V	3.34x34	Structure	Structure
TM3	123	S	3.35x35	Structure	Structure
TM3	124	I	3.36x36	Structure	Structure
TM3	125	T	3.37x37	Structure	Structure
TM3	126	V	3.38x38	Structure	Structure
TM3	127	S	3.39x39	Structure	Structure
TM3	128	I	3.40x40	Structure	Structure
TM3	129	F	3.41x41	Structure	Structure
TM3	130	S	3.42x42	Structure	Structure
TM3	131	L	3.43x43	Structure	Structure
TM3	132	V	3.44x44	Structure	Structure
TM3	133	L	3.45x45	Structure	Structure
TM3	134	I	3.46x46	Structure	Structure
TM3	135	A	3.47x47	Structure	Structure
TM3	136	V	3.48x48	Structure	Structure
TM3	137	E	3.49x49	Structure	Structure
TM3	138	R	3.50x50	Structure	Structure
TM3	139	H	3.51x51	Structure	Structure
TM3	140	Q	3.52x52	Structure	Structure
TM3	141	L	3.53x53	Structure	Structure
TM3	142	I	3.54x54	Structure	Structure
TM3	143	I	3.55x55	Structure	Structure
TM3	144	N	3.56x56	Structure	Structure
ICL2	145	P	-	Structure	Structure
ICL2	146	R	-	Structure	Structure
ICL2	147	G	-	Structure	Structure
ICL2	148	W	-	Structure	Structure
ICL2	149	R	-	Structure	Structure
ICL2	150	P	-	Structure	Structure
TM4	151	N	4.38x38	Structure	Structure
TM4	152	N	4.39x39	Structure	Structure
TM4	153	R	4.40x40	Structure	Structure
TM4	154	H	4.41x41	Structure	Structure
TM4	155	A	4.42x42	Structure	Structure
TM4	156	Y	4.43x43	Structure	Structure
TM4	157	V	4.44x44	Structure	Structure
TM4	158	G	4.45x45	Structure	Structure
TM4	159	I	4.46x46	Structure	Structure
TM4	160	A	4.47x47	Structure	Structure
TM4	161	V	4.48x48	Structure	Structure
TM4	162	I	4.49x49	Structure	Structure
TM4	163	W	4.50x50	Structure	Structure
TM4	164	V	4.51x51	Structure	Structure
TM4	165	L	4.52x52	Structure	Structure
TM4	166	A	4.53x53	Structure	Structure
TM4	167	V	4.54x54	Structure	Structure
TM4	168	A	4.55x55	Structure	Structure
TM4	169	S	4.56x56	Structure	Structure
TM4	170	S	4.57x57	Structure	Structure
TM4	171	L	4.58x59	Structure	Structure
TM4	172	P	4.59x60	Structure	Structure
TM4	173	F	4.60x61	Structure	Structure
TM4	174	L	4.61x62	Structure	Structure
TM4	175	I	4.62x63	Structure	Structure
TM4	176	Y	4.63x64	Structure	Structure
TM4	177	Q	4.64x65	Structure	Structure
ECL2	178	V	-	Structure	Structure
ECL2	179	M	-	Structure	Structure
ECL2	180	T	-	Structure	Structure
ECL2	181	D	-	Structure	Structure
ECL2	182	E	-	Structure	AF2
ECL2	183	P	-	Structure	Structure
ECL2	184	F	-	Structure	Structure
ECL2	185	Q	-	Structure	AF2
ECL2	186	N	-	Structure	AF2
ECL2	187	V	-	Structure	Structure
ECL2	188	T	-	Structure	Structure
ECL2	189	L	-	Structure	AF2
ECL2	190	D	-	Structure	Structure
ECL2	191	A	-	Structure	Structure
ECL2	192	Y	-	Structure	Structure
ECL2	193	K	-	Structure	AF2
ECL2	194	D	-	Structure	Structure
ECL2	195	K	-	Structure	AF2
ECL2	196	Y	-	Structure	Structure
ECL2	197	V	-	Structure	Structure
ECL2	198	C	45.50x50	Structure	Structure
ECL2	199	F	45.51x51	Structure	Structure
ECL2	200	D	45.52x52	Structure	Structure
ECL2	201	Q	-	Structure	Structure
ECL2	202	F	-	Structure	Structure
ECL2	203	P	-	Structure	Structure
TM5	204	S	5.31x32	Structure	Structure
TM5	205	D	5.32x33	Structure	Structure
TM5	206	S	5.33x34	Structure	Structure
TM5	207	H	5.34x35	Structure	Structure
TM5	208	R	5.35x36	Structure	Structure
TM5	209	L	5.36x37	Structure	Structure
TM5	210	S	5.37x38	Structure	Structure
TM5	211	Y	5.38x39	Structure	Structure
TM5	212	T	5.39x40	Structure	Structure
TM5	213	T	5.40x41	Structure	Structure
TM5	214	L	5.41x42	Structure	Structure
TM5	215	L	5.42x43	Structure	Structure
TM5	216	L	5.43x44	Structure	Structure
TM5	217	V	5.44x45	Structure	Structure
TM5	218	L	5.45x46	Structure	Structure
TM5	219	Q	5.46x461	Structure	Structure
TM5	220	Y	5.47x47	Structure	Structure
TM5	221	F	5.48x48	Structure	Structure
TM5	222	G	5.49x49	Structure	Structure
TM5	223	P	5.50x50	Structure	Structure
TM5	224	L	5.51x51	Structure	Structure
TM5	225	C	5.52x52	Structure	Structure
TM5	226	F	5.53x53	Structure	Structure
TM5	227	I	5.54x54	Structure	Structure
TM5	228	F	5.55x55	Structure	Structure
TM5	229	I	5.56x56	Structure	Structure
TM5	230	C	5.57x57	Structure	Structure
TM5	231	Y	5.58x58	Structure	Structure
TM5	232	F	5.59x59	Structure	Structure
TM5	233	K	5.60x60	Structure	Structure
TM5	234	I	5.61x61	Structure	Structure
TM5	235	Y	5.62x62	Structure	Structure
TM5	236	I	5.63x63	Structure	Structure
TM5	237	R	5.64x64	Structure	Structure
TM5	238	L	5.65x65	Structure	Structure
TM5	239	K	5.66x66	Structure	Structure
TM5	240	R	5.67x67	Structure	Structure
TM5	241	R	5.68x68	Structure	Structure
TM5	242	N	5.69x69	Structure	Structure
TM5	243	N	5.70x70	Structure	Structure
TM5	244	M	5.71x71	Structure	Structure
TM5	245	M	5.72x72	Structure	Structure
TM5	246	D	5.73x73	Structure	Structure
ICL3	247	K	-	Structure	AF2
ICL3	248	M	-	Structure	Structure
ICL3	249	R	-	Structure	AF2
TM6	250	D	6.22x22	Structure	AF2
TM6	251	N	6.23x23	Structure	AF2
TM6	252	K	6.24x24	Structure	AF2
TM6	253	Y	6.25x25	Structure	Structure
TM6	254	R	6.26x26	Structure	AF2
TM6	255	S	6.27x27	Structure	Structure
TM6	256	S	6.28x28	Structure	Structure
TM6	257	E	6.29x29	Structure	Structure
TM6	258	T	6.30x30	Structure	Structure
TM6	259	K	6.31x31	Structure	Structure
TM6	260	R	6.32x32	Structure	Structure
TM6	261	I	6.33x33	Structure	Structure
TM6	262	N	6.34x34	Structure	Structure
TM6	263	I	6.35x35	Structure	Structure
TM6	264	M	6.36x36	Structure	Structure
TM6	265	L	6.37x37	Structure	Structure
TM6	266	L	6.38x38	Structure	Structure
TM6	267	S	6.39x39	Structure	Structure
TM6	268	I	6.40x40	Structure	Structure
TM6	269	V	6.41x41	Structure	Structure
TM6	270	V	6.42x42	Structure	Structure
TM6	271	A	6.43x43	Structure	Structure
TM6	272	F	6.44x44	Structure	Structure
TM6	273	A	6.45x45	Structure	Structure
TM6	274	V	6.46x46	Structure	Structure
TM6	275	C	6.47x47	Structure	Structure
TM6	276	W	6.48x48	Structure	Structure
TM6	277	L	6.49x49	Structure	Structure
TM6	278	P	6.50x50	Structure	Structure
TM6	279	L	6.51x51	Structure	Structure
TM6	280	T	6.52x52	Structure	Structure
TM6	281	I	6.53x53	Structure	Structure
TM6	282	F	6.54x54	Structure	Structure
TM6	283	N	6.55x55	Structure	Structure
TM6	284	T	6.56x56	Structure	Structure
TM6	285	V	6.57x57	Structure	Structure
TM6	286	F	6.58x58	Structure	Structure
TM6	287	D	6.59x59	Structure	Structure
TM6	288	W	6.60x60	Structure	Structure
TM6	289	N	6.61x61	Structure	AF2
ECL3	290	H	-	Structure	AF2
ECL3	291	Q	-	Structure	AF2
ECL3	292	I	-	Structure	Structure
ECL3	293	I	-	Structure	Structure
ECL3	294	A	-	Structure	Structure
TM7	295	T	7.28x27	Structure	Structure
TM7	296	C	7.29x28	Structure	Structure
TM7	297	N	7.30x29	Structure	Structure
TM7	298	H	7.31x30	Structure	Structure
TM7	299	N	7.32x31	Structure	Structure
TM7	300	L	7.33x32	Structure	Structure
TM7	301	L	7.34x33	Structure	Structure
TM7	302	F	7.35x34	Structure	Structure
TM7	303	L	7.36x35	Structure	Structure
TM7	304	L	7.37x36	Structure	Structure
TM7	305	C	7.38x37	Structure	Structure
TM7	306	H	7.39x38	Structure	Structure
TM7	307	L	7.40x39	Structure	Structure
TM7	308	T	7.41x40	Structure	Structure
TM7	309	A	7.42x41	Structure	Structure
TM7	310	M	7.43x42	Structure	AF2
TM7	311	I	7.44x43	Structure	Structure
TM7	312	S	7.45x45	Structure	Structure
TM7	313	T	7.46x46	Structure	Structure
TM7	314	C	7.47x47	Structure	Structure
TM7	315	V	7.48x48	Structure	Structure
TM7	316	N	7.49x49	Structure	Structure
TM7	317	P	7.50x50	Structure	Structure
TM7	318	I	7.51x51	Structure	Structure
TM7	319	F	7.52x52	Structure	Structure
TM7	320	Y	7.53x53	Structure	Structure
TM7	321	G	7.54x54	Structure	Structure
TM7	322	F	7.55x55	Structure	Structure
TM7	323	L	7.56x56	Structure	Structure
H8	324	N	8.47x47	Structure	Structure
H8	325	K	8.48x48	Structure	Structure
H8	326	N	8.49x49	Structure	Structure
H8	327	F	8.50x50	Structure	Structure
H8	328	Q	8.51x51	Structure	Structure
H8	329	R	8.52x52	Structure	AF2
H8	330	D	8.53x53	Structure	Structure
H8	331	L	8.54x54	Structure	Structure
H8	332	Q	8.55x55	Structure	AF2
H8	333	F	8.56x56	Structure	Structure
H8	334	F	8.57x57	Structure	Structure
H8	335	F	8.58x58	Structure	AF2
C-term	336	N	-	Structure	Structure
C-term	337	F	-	AF2	AF2
C-term	338	C	-	AF2	AF2
C-term	339	D	-	AF2	AF2
C-term	340	F	-	AF2	AF2
C-term	341	R	-	AF2	AF2
C-term	342	S	-	AF2	AF2
C-term	343	R	-	AF2	AF2
C-term	344	D	-	AF2	AF2
C-term	345	D	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	TM7	L	323	7x56	G.H5	F	354	G.H5.26
Hydrophobic	ICL3	R	249	-	G.h4s6	K	314	G.h4s6.08
Hydrophobic	TM6	N	251	6x23	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM3	R	138	3x50	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	R	146	-	G.H5	F	336	G.H5.08
Hydrophobic	ICL3	M	248	-	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM3	L	141	3x53	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	P	145	-	G.H5	I	343	G.H5.15
Hydrophobic	TM3	I	142	3x54	G.H5	N	347	G.H5.19
Hydrophobic	TM5	M	245	5x72	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM6	M	264	6x36	G.H5	L	353	G.H5.25
Hydrophobic	TM5	R	241	5x68	G.H5	D	341	G.H5.13
Hydrophobic	TM6	I	261	6x33	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	P	145	-	G.H5	I	344	G.H5.16
Hydrophobic	H8	N	324	8x47	G.H5	F	354	G.H5.26
Hydrophobic	TM6	I	261	6x33	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	W	148	-	G.H5	N	347	G.H5.19
Hydrophobic	TM3	R	138	3x50	G.H5	L	353	G.H5.25
Hydrophobic	TM3	I	142	3x54	G.H5	L	348	G.H5.20
Hydrophobic	TM6	M	264	6x36	G.H5	F	354	G.H5.26
Hydrophobic	H8	N	324	8x47	G.H5	G	352	G.H5.24
Hydrophobic	TM3	I	142	3x54	G.H5	I	344	G.H5.16
Hydrophobic	H8	K	325	8x48	G.H5	K	349	G.H5.21
Hydrophobic	TM6	I	261	6x33	G.H5	L	353	G.H5.25
Hydrophobic	TM5	R	241	5x68	G.H5	I	344	G.H5.16
Hydrophobic	ICL2	R	146	-	G.H5	I	343	G.H5.15
Hydrophobic	TM5	L	238	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM3	L	141	3x53	G.H5	N	347	G.H5.19
Hydrophobic	ICL2	R	146	-	G.S3	L	194	G.S3.01
Hydrophobic	TM6	R	260	6x32	G.H5	F	354	G.H5.26
Hydrophobic	TM6	R	254	6x26	G.h4s6	E	318	G.h4s6.12
Hydrophobic	H8	K	325	8x48	G.H5	F	354	G.H5.26
Hydrophobic	TM2	T	75	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM6	Y	253	6x25	G.h4s6	D	315	G.h4s6.09
Ionic	TM5	R	241	5x68	G.H5	D	341	G.H5.13
Ionic	TM6	E	257	6x29	G.H5	K	345	G.H5.17
Ionic	TM6	R	254	6x26	G.h4s6	E	318	G.h4s6.12
Polar	TM6	N	251	6x23	G.h4s6	E	318	G.h4s6.12
Polar	TM3	R	138	3x50	G.H5	C	351	G.H5.23
Polar	TM2	N	73	2x37	G.H5	D	350	G.H5.22
Polar	H8	N	326	8x49	G.H5	K	349	G.H5.21
Polar	ICL2	R	146	-	G.H5	T	340	G.H5.12
Polar	TM6	E	257	6x29	G.H5	K	345	G.H5.17
Polar	H8	K	325	8x48	G.H5	K	349	G.H5.21
Polar	TM6	R	260	6x32	G.H5	F	354	G.H5.26
Polar	TM6	R	254	6x26	G.h4s6	E	318	G.h4s6.12
Polar	TM2	T	75	2x39	G.H5	C	351	G.H5.23
Van-der-waals	TM7	L	323	7x56	G.H5	F	354	G.H5.26
Van-der-waals	ICL3	R	249	-	G.h4s6	K	314	G.h4s6.08
Van-der-waals	TM6	N	251	6x23	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM3	R	138	3x50	G.H5	C	351	G.H5.23
Van-der-waals	ICL3	M	248	-	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM2	N	73	2x37	G.H5	D	350	G.H5.22
Van-der-waals	ICL2	P	145	-	G.H5	I	343	G.H5.15
Van-der-waals	TM6	E	257	6x29	G.H5	F	354	G.H5.26
Van-der-waals	TM5	M	245	5x72	G.h4s6	E	318	G.h4s6.12
Van-der-waals	H8	N	326	8x49	G.H5	K	349	G.H5.21
Van-der-waals	ICL2	R	146	-	G.H5	T	340	G.H5.12
Van-der-waals	ICL2	P	145	-	G.H5	I	344	G.H5.16
Van-der-waals	TM6	I	261	6x33	G.H5	F	354	G.H5.26
Van-der-waals	TM6	E	257	6x29	G.H5	K	345	G.H5.17
Van-der-waals	ICL2	W	148	-	G.H5	N	347	G.H5.19
Van-der-waals	TM3	R	138	3x50	G.H5	L	353	G.H5.25
Van-der-waals	TM3	I	142	3x54	G.H5	L	348	G.H5.20
Van-der-waals	H8	N	324	8x47	G.H5	G	352	G.H5.24
Van-der-waals	TM3	I	142	3x54	G.H5	I	344	G.H5.16
Van-der-waals	H8	K	325	8x48	G.H5	K	349	G.H5.21
Van-der-waals	TM6	I	261	6x33	G.H5	L	353	G.H5.25
Van-der-waals	TM3	L	141	3x53	G.H5	N	347	G.H5.19
Van-der-waals	TM6	R	260	6x32	G.H5	F	354	G.H5.26
Van-der-waals	TM6	R	254	6x26	G.h4s6	E	318	G.h4s6.12
Van-der-waals	H8	K	325	8x48	G.H5	F	354	G.H5.26
Van-der-waals	TM2	T	75	2x39	G.H5	C	351	G.H5.23
Van-der-waals	TM6	Y	253	6x25	G.h4s6	D	315	G.h4s6.09

Showing 1 to 74 of 74 entries

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Refined structure (7X9A) of Gi1 - Y1 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (7X9A) of G_i1 - Y₁ receptor

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