Refined structure (8E3Z) of Gs - VPAC1 receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (55.1%), 177 from model (44.9%)
Residue sidechains - 208 from structure (52.8%), 186 from model (47.2%)

REFINED GPCR RESIDUES

Residue backbones - 372 from structure (87.1%), 55 from model (12.9%)
Residue sidechains - 337 from structure (78.9%), 90 from model (21.1%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
H02G.S1F08R12Q16R17Q22L25G.H5GproteinK5x64F-S-R2x46A3x59S6x41GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.S1G.H5GPCR segments:TM2ICL2TM3TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x493x503x533x543x554x405x655x685x696x366x396x408x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.08G.S6.03G.H4.16G.H4.12G.hgh4.13G.S3.03G.S3.01G.S1.02G.HN.52Res. Pos.VPAC1 (8E3Z_REFINED)- (8E3Z_REFINED)----------------RYLLLARLKLSLLNGRYLLLARLKLSLLNGDQYLHQLRQLDRERLFCIHVFPD

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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