Biased Signaling Atlas

Refined structure (8HVI) of G_i1 - GPR132

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-07-12

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 214 from structure (60.5%), 140 from model (39.5%)
Residue sidechains - 209 from structure (59.0%), 145 from model (41.0%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	AF2	AF2
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	AF2
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	Structure
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	AF2
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	Structure
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	Structure	Structure
G.s4h3	234	L	G.s4h3.08	Structure	Structure
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	Structure	Structure
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	Structure
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	Structure
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	Structure
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	AF2	AF2
G.HG	280	K	G.HG.12	AF2	AF2
G.HG	281	S	G.HG.13	AF2	AF2
G.HG	282	P	G.HG.14	AF2	AF2
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	Structure
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	Structure
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	AF2
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 303 from structure (88.9%), 38 from model (11.1%)
Residue sidechains - 301 from structure (88.3%), 40 from model (11.7%)

Showing 1 to 341 of 341 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	C	-	AF2	AF2
N-term	3	P	-	AF2	AF2
N-term	4	M	-	AF2	AF2
N-term	5	L	-	AF2	AF2
N-term	6	L	-	AF2	AF2
N-term	7	K	-	AF2	AF2
N-term	8	N	-	AF2	AF2
N-term	9	G	-	AF2	AF2
N-term	10	Y	-	AF2	AF2
N-term	11	N	-	AF2	AF2
N-term	12	G	-	AF2	AF2
N-term	13	N	-	AF2	AF2
N-term	14	A	-	AF2	AF2
N-term	15	T	-	AF2	AF2
N-term	16	P	-	AF2	AF2
N-term	17	V	-	AF2	AF2
N-term	18	T	-	AF2	AF2
N-term	19	T	-	AF2	AF2
N-term	20	T	-	AF2	AF2
N-term	21	A	-	AF2	AF2
N-term	22	P	-	AF2	AF2
N-term	23	W	-	AF2	AF2
N-term	24	A	-	AF2	AF2
N-term	25	S	-	AF2	AF2
N-term	26	L	-	AF2	AF2
N-term	27	G	-	AF2	AF2
N-term	28	L	-	AF2	AF2
N-term	29	S	-	AF2	AF2
N-term	30	A	-	AF2	AF2
N-term	31	K	-	AF2	AF2
N-term	32	T	-	AF2	AF2
N-term	33	C	-	AF2	AF2
N-term	34	N	-	AF2	AF2
N-term	35	N	-	AF2	AF2
N-term	36	V	-	AF2	AF2
TM1	37	S	1.27x27	AF2	AF2
TM1	38	F	1.28x28	AF2	AF2
TM1	39	E	1.29x29	Structure	Structure
TM1	40	E	1.30x30	Structure	Structure
TM1	41	S	1.31x31	Structure	Structure
TM1	42	R	1.32x32	Structure	Structure
TM1	43	I	1.33x33	Structure	Structure
TM1	44	V	1.34x34	Structure	Structure
TM1	45	L	1.35x35	Structure	Structure
TM1	46	V	1.36x36	Structure	Structure
TM1	47	V	1.37x37	Structure	Structure
TM1	48	V	1.38x38	Structure	Structure
TM1	49	Y	1.39x39	Structure	Structure
TM1	50	S	1.40x40	Structure	Structure
TM1	51	A	1.41x41	Structure	Structure
TM1	52	V	1.42x42	Structure	Structure
TM1	53	C	1.43x43	Structure	Structure
TM1	54	T	1.44x44	Structure	Structure
TM1	55	L	1.45x45	Structure	Structure
TM1	56	G	1.46x46	Structure	Structure
TM1	57	V	1.47x47	Structure	Structure
TM1	58	P	1.48x48	Structure	Structure
TM1	59	A	1.49x49	Structure	Structure
TM1	60	N	1.50x50	Structure	Structure
TM1	61	C	1.51x51	Structure	Structure
TM1	62	L	1.52x52	Structure	Structure
TM1	63	T	1.53x53	Structure	Structure
TM1	64	A	1.54x54	Structure	Structure
TM1	65	W	1.55x55	Structure	Structure
TM1	66	L	1.56x56	Structure	Structure
TM1	67	A	1.57x57	Structure	Structure
TM1	68	L	1.58x58	Structure	Structure
TM1	69	L	1.59x59	Structure	Structure
TM1	70	Q	1.60x60	Structure	Structure
TM1	71	V	1.61x61	Structure	Structure
ICL1	72	L	-	Structure	Structure
ICL1	73	Q	-	Structure	Structure
ICL1	74	G	-	Structure	Structure
TM2	75	N	2.37x37	Structure	Structure
TM2	76	V	2.38x38	Structure	Structure
TM2	77	L	2.39x39	Structure	Structure
TM2	78	A	2.40x40	Structure	Structure
TM2	79	V	2.41x41	Structure	Structure
TM2	80	Y	2.42x42	Structure	Structure
TM2	81	L	2.43x43	Structure	Structure
TM2	82	L	2.44x44	Structure	Structure
TM2	83	C	2.45x45	Structure	Structure
TM2	84	L	2.46x46	Structure	Structure
TM2	85	A	2.47x47	Structure	Structure
TM2	86	L	2.48x48	Structure	Structure
TM2	87	C	2.49x49	Structure	Structure
TM2	88	E	2.50x50	Structure	Structure
TM2	89	L	2.51x51	Structure	Structure
TM2	90	L	2.52x52	Structure	Structure
TM2	91	Y	2.53x53	Structure	Structure
TM2	92	T	2.54x54	Structure	Structure
TM2	93	G	2.55x55	Structure	Structure
TM2	94	T	2.56x56	Structure	Structure
TM2	95	L	2.57x57	Structure	Structure
TM2	96	P	2.58x58	Structure	Structure
TM2	97	L	2.59x59	Structure	Structure
TM2	98	W	2.60x60	Structure	Structure
TM2	99	V	2.61x61	Structure	Structure
TM2	100	I	2.62x62	Structure	Structure
TM2	101	Y	2.63x63	Structure	Structure
TM2	102	I	2.64x64	Structure	Structure
ECL1	103	R	-	Structure	Structure
ECL1	104	N	-	Structure	Structure
ECL1	105	Q	-	Structure	Structure
ECL1	106	H	-	Structure	Structure
ECL1	107	R	23.49x49	Structure	Structure
ECL1	108	W	23.50x50	Structure	Structure
ECL1	109	T	23.51x51	Structure	Structure
ECL1	110	L	23.52x52	Structure	Structure
TM3	111	G	3.21x21	Structure	Structure
TM3	112	L	3.22x22	Structure	Structure
TM3	113	L	3.23x23	Structure	Structure
TM3	114	A	3.24x24	Structure	Structure
TM3	115	C	3.25x25	Structure	Structure
TM3	116	K	3.26x26	Structure	Structure
TM3	117	V	3.27x27	Structure	Structure
TM3	118	T	3.28x28	Structure	Structure
TM3	119	A	3.29x29	Structure	Structure
TM3	120	Y	3.30x30	Structure	Structure
TM3	121	I	3.31x31	Structure	Structure
TM3	122	F	3.32x32	Structure	Structure
TM3	123	F	3.33x33	Structure	Structure
TM3	124	C	3.34x34	Structure	Structure
TM3	125	N	3.35x35	Structure	Structure
TM3	126	I	3.36x36	Structure	Structure
TM3	127	Y	3.37x37	Structure	Structure
TM3	128	V	3.38x38	Structure	Structure
TM3	129	S	3.39x39	Structure	Structure
TM3	130	I	3.40x40	Structure	Structure
TM3	131	L	3.41x41	Structure	Structure
TM3	132	F	3.42x42	Structure	Structure
TM3	133	L	3.43x43	Structure	Structure
TM3	134	C	3.44x44	Structure	Structure
TM3	135	C	3.45x45	Structure	Structure
TM3	136	I	3.46x46	Structure	Structure
TM3	137	S	3.47x47	Structure	Structure
TM3	138	C	3.48x48	Structure	Structure
TM3	139	D	3.49x49	Structure	Structure
TM3	140	R	3.50x50	Structure	Structure
TM3	141	F	3.51x51	Structure	Structure
TM3	142	V	3.52x52	Structure	Structure
TM3	143	A	3.53x53	Structure	Structure
TM3	144	V	3.54x54	Structure	Structure
TM3	145	V	3.55x55	Structure	Structure
TM3	146	Y	3.56x56	Structure	Structure
ICL2	147	A	34.50x50	Structure	Structure
ICL2	148	L	34.51x51	Structure	Structure
ICL2	149	E	34.52x52	Structure	Structure
ICL2	150	S	34.53x53	Structure	Structure
ICL2	151	R	34.54x54	Structure	Structure
ICL2	152	G	34.55x55	Structure	Structure
ICL2	153	R	34.56x56	Structure	Structure
ICL2	154	R	34.57x57	Structure	Structure
TM4	155	R	4.38x38	Structure	Structure
TM4	156	R	4.39x39	Structure	Structure
TM4	157	R	4.40x40	Structure	Structure
TM4	158	T	4.41x41	Structure	Structure
TM4	159	A	4.42x42	Structure	Structure
TM4	160	I	4.43x43	Structure	Structure
TM4	161	L	4.44x44	Structure	Structure
TM4	162	I	4.45x45	Structure	Structure
TM4	163	S	4.46x46	Structure	Structure
TM4	164	A	4.47x47	Structure	Structure
TM4	165	C	4.48x48	Structure	Structure
TM4	166	I	4.49x49	Structure	Structure
TM4	167	F	4.50x50	Structure	Structure
TM4	168	I	4.51x51	Structure	Structure
TM4	169	L	4.52x52	Structure	Structure
TM4	170	V	4.53x53	Structure	Structure
TM4	171	G	4.54x54	Structure	Structure
TM4	172	I	4.55x55	Structure	Structure
TM4	173	V	4.56x56	Structure	Structure
TM4	174	H	4.57x57	Structure	AF2
TM4	175	Y	4.58x59	Structure	Structure
TM4	176	P	4.59x60	Structure	Structure
TM4	177	V	4.60x61	Structure	Structure
TM4	178	F	4.61x62	Structure	Structure
TM4	179	Q	4.62x63	Structure	Structure
TM4	180	T	4.63x64	Structure	Structure
ECL2	181	E	-	Structure	Structure
ECL2	182	D	-	Structure	Structure
ECL2	183	K	-	Structure	Structure
ECL2	184	E	-	Structure	Structure
ECL2	185	T	-	Structure	Structure
ECL2	186	C	45.50x50	Structure	Structure
ECL2	187	F	45.51x51	Structure	Structure
ECL2	188	D	45.52x52	Structure	Structure
ECL2	189	M	-	Structure	Structure
ECL2	190	L	-	Structure	Structure
ECL2	191	Q	-	Structure	Structure
ECL2	192	M	-	Structure	Structure
TM5	193	D	5.32x33	Structure	Structure
TM5	194	S	5.33x34	Structure	Structure
TM5	195	R	5.34x35	Structure	Structure
TM5	196	I	5.35x36	Structure	Structure
TM5	197	A	5.36x37	Structure	Structure
TM5	198	G	5.37x38	Structure	Structure
TM5	199	Y	5.38x39	Structure	Structure
TM5	200	Y	5.39x40	Structure	Structure
TM5	201	Y	5.40x41	Structure	Structure
TM5	202	A	5.41x42	Structure	Structure
TM5	203	R	5.42x43	Structure	Structure
TM5	204	F	5.43x44	Structure	AF2
TM5	205	T	5.44x45	Structure	Structure
TM5	206	V	5.45x46	Structure	Structure
TM5	207	G	5.46x461	Structure	Structure
TM5	208	F	5.47x47	Structure	Structure
TM5	209	A	5.48x48	Structure	Structure
TM5	210	I	5.49x49	Structure	Structure
TM5	211	P	5.50x50	Structure	Structure
TM5	212	L	5.51x51	Structure	Structure
TM5	213	S	5.52x52	Structure	Structure
TM5	214	I	5.53x53	Structure	Structure
TM5	215	I	5.54x54	Structure	Structure
TM5	216	A	5.55x55	Structure	Structure
TM5	217	F	5.56x56	Structure	Structure
TM5	218	T	5.57x57	Structure	Structure
TM5	219	N	5.58x58	Structure	Structure
TM5	220	H	5.59x59	Structure	Structure
TM5	221	R	5.60x60	Structure	Structure
TM5	222	I	5.61x61	Structure	Structure
TM5	223	F	5.62x62	Structure	Structure
TM5	224	R	5.63x63	Structure	Structure
TM5	225	S	5.64x64	Structure	Structure
TM5	226	I	5.65x65	Structure	Structure
TM5	227	K	5.66x66	Structure	Structure
TM5	228	Q	5.67x67	Structure	Structure
TM5	229	S	5.68x68	Structure	Structure
ICL3	230	M	-	Structure	Structure
ICL3	231	G	-	Structure	Structure
ICL3	232	L	-	Structure	Structure
TM6	233	S	6.26x26	Structure	Structure
TM6	234	A	6.27x27	Structure	Structure
TM6	235	A	6.28x28	Structure	Structure
TM6	236	Q	6.29x29	Structure	Structure
TM6	237	K	6.30x30	Structure	Structure
TM6	238	A	6.31x31	Structure	Structure
TM6	239	K	6.32x32	Structure	Structure
TM6	240	V	6.33x33	Structure	Structure
TM6	241	K	6.34x34	Structure	Structure
TM6	242	H	6.35x35	Structure	Structure
TM6	243	S	6.36x36	Structure	Structure
TM6	244	A	6.37x37	Structure	Structure
TM6	245	I	6.38x38	Structure	Structure
TM6	246	A	6.39x39	Structure	Structure
TM6	247	V	6.40x40	Structure	Structure
TM6	248	V	6.41x41	Structure	Structure
TM6	249	V	6.42x42	Structure	Structure
TM6	250	I	6.43x43	Structure	Structure
TM6	251	F	6.44x44	Structure	Structure
TM6	252	L	6.45x45	Structure	Structure
TM6	253	V	6.46x46	Structure	Structure
TM6	254	C	6.47x47	Structure	Structure
TM6	255	F	6.48x48	Structure	Structure
TM6	256	A	6.49x49	Structure	Structure
TM6	257	P	6.50x50	Structure	Structure
TM6	258	Y	6.51x51	Structure	Structure
TM6	259	H	6.52x52	Structure	Structure
TM6	260	L	6.53x53	Structure	Structure
TM6	261	V	6.54x54	Structure	Structure
TM6	262	L	6.55x55	Structure	Structure
TM6	263	L	6.56x56	Structure	Structure
TM6	264	V	6.57x57	Structure	Structure
TM6	265	K	6.58x58	Structure	Structure
TM6	266	A	6.59x59	Structure	Structure
TM6	267	A	6.60x60	Structure	Structure
TM6	268	A	6.61x61	Structure	Structure
TM6	269	F	6.62x62	Structure	Structure
TM6	270	S	6.63x63	Structure	Structure
TM6	271	Y	6.64x64	Structure	Structure
TM6	272	Y	6.65x65	Structure	Structure
TM6	273	R	6.66x66	Structure	Structure
ECL3	274	G	-	Structure	Structure
ECL3	275	D	-	Structure	Structure
ECL3	276	R	-	Structure	Structure
ECL3	277	N	-	Structure	Structure
TM7	278	A	7.23x22	Structure	Structure
TM7	279	M	7.24x23	Structure	Structure
TM7	280	C	7.25x24	Structure	Structure
TM7	281	G	7.26x25	Structure	Structure
TM7	282	L	7.27x26	Structure	Structure
TM7	283	E	7.28x27	Structure	Structure
TM7	284	E	7.29x28	Structure	Structure
TM7	285	R	7.30x29	Structure	Structure
TM7	286	L	7.31x30	Structure	Structure
TM7	287	Y	7.32x31	Structure	Structure
TM7	288	T	7.33x32	Structure	Structure
TM7	289	A	7.34x33	Structure	Structure
TM7	290	S	7.35x34	Structure	Structure
TM7	291	V	7.36x35	Structure	Structure
TM7	292	V	7.37x36	Structure	Structure
TM7	293	F	7.38x37	Structure	Structure
TM7	294	L	7.39x38	Structure	Structure
TM7	295	C	7.40x39	Structure	Structure
TM7	296	L	7.41x40	Structure	Structure
TM7	297	S	7.42x41	Structure	Structure
TM7	298	T	7.43x42	Structure	Structure
TM7	299	V	7.44x43	Structure	Structure
TM7	300	N	7.45x45	Structure	Structure
TM7	301	G	7.46x46	Structure	Structure
TM7	302	V	7.47x47	Structure	Structure
TM7	303	A	7.48x48	Structure	Structure
TM7	304	D	7.49x49	Structure	Structure
TM7	305	P	7.50x50	Structure	Structure
TM7	306	I	7.51x51	Structure	Structure
TM7	307	I	7.52x52	Structure	Structure
TM7	308	Y	7.53x53	Structure	Structure
TM7	309	V	7.54x54	Structure	Structure
TM7	310	L	7.55x55	Structure	Structure
TM7	311	A	7.56x56	Structure	Structure
H8	312	T	8.47x47	Structure	Structure
H8	313	D	8.48x48	Structure	Structure
H8	314	H	8.49x49	Structure	Structure
H8	315	S	8.50x50	Structure	Structure
H8	316	R	8.51x51	Structure	Structure
H8	317	Q	8.52x52	Structure	Structure
H8	318	E	8.53x53	Structure	Structure
H8	319	V	8.54x54	Structure	Structure
H8	320	S	8.55x55	Structure	Structure
H8	321	R	8.56x56	Structure	Structure
H8	322	I	8.57x57	Structure	Structure
H8	323	H	8.58x58	Structure	Structure
H8	324	K	8.59x59	Structure	Structure
H8	325	G	8.60x60	Structure	Structure
H8	326	W	8.61x61	Structure	Structure
H8	327	K	8.62x62	Structure	Structure
H8	328	E	8.63x63	Structure	Structure
H8	329	W	8.64x64	Structure	Structure
H8	330	S	8.65x65	Structure	Structure
H8	331	M	8.66x66	Structure	Structure
C-term	332	K	-	Structure	Structure
C-term	333	T	-	Structure	Structure
C-term	334	D	-	Structure	Structure
C-term	335	V	-	Structure	Structure
C-term	336	T	-	Structure	Structure
C-term	337	R	-	Structure	Structure
C-term	338	L	-	Structure	Structure
C-term	339	T	-	Structure	Structure
C-term	340	H	-	Structure	Structure
C-term	341	S	-	Structure	Structure

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	TM6	Q	236	6x29	G.H5	F	354	G.H5.26
Hydrophobic	TM2	L	77	2x39	G.H5	D	350	G.H5.22
Hydrophobic	TM2	L	77	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM3	R	140	3x50	G.H5	C	351	G.H5.23
Hydrophobic	TM6	V	240	6x33	G.H5	L	353	G.H5.25
Hydrophobic	TM6	K	239	6x32	G.H5	F	354	G.H5.26
Hydrophobic	TM6	S	243	6x36	G.H5	L	353	G.H5.25
Hydrophobic	TM6	V	240	6x33	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	A	147	34x50	G.H5	I	344	G.H5.16
Hydrophobic	ICL3	L	232	-	G.H5	L	348	G.H5.20
Polar	TM3	A	143	3x53	G.H5	N	347	G.H5.19
Polar	ICL3	G	231	-	G.H5	K	345	G.H5.17
Polar	TM3	R	140	3x50	G.H5	C	351	G.H5.23
Polar	TM6	K	239	6x32	G.H5	L	353	G.H5.25
Polar	TM2	N	75	2x37	G.H5	D	350	G.H5.22
Van-der-waals	TM3	A	143	3x53	G.H5	N	347	G.H5.19
Van-der-waals	TM6	Q	236	6x29	G.H5	F	354	G.H5.26
Van-der-waals	TM2	L	77	2x39	G.H5	D	350	G.H5.22
Van-der-waals	TM2	L	77	2x39	G.H5	C	351	G.H5.23
Van-der-waals	TM3	R	140	3x50	G.H5	C	351	G.H5.23
Van-der-waals	TM6	V	240	6x33	G.H5	L	353	G.H5.25
Van-der-waals	TM6	K	239	6x32	G.H5	F	354	G.H5.26
Van-der-waals	TM6	S	243	6x36	G.H5	L	353	G.H5.25
Van-der-waals	TM2	N	75	2x37	G.H5	D	350	G.H5.22

Showing 1 to 24 of 24 entries

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Main reference

Refined structure (8HVI) of Gi1 - GPR132 Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8HVI) of G_i1 - GPR132

Full