Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5XPR

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

A

REFERENCE

10.1038/NSMB.3450

PUBLICATION DATE

Aug. 16, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bosentan D154 2.57x56 TM2 polar (charge-assisted hydrogen bond)
bosentan P178 3.29x29 TM3 hydrophobic
bosentan P178 3.29x29 TM3 Van der Waals
bosentan Q181 3.32x32 TM3 Van der Waals
bosentan Q181 3.32x32 TM3 polar (hydrogen bond)
bosentan K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
bosentan V185 3.36x36 TM3 hydrophobic
bosentan V185 3.36x36 TM3 Van der Waals
bosentan K273 5.38x39 TM5 polar (charge-assisted hydrogen bond)
bosentan L277 5.42x43 TM5 Van der Waals
bosentan L277 5.42x43 TM5 hydrophobic
bosentan Y281 5.46x461 TM5 hydrophobic
bosentan Y281 5.46x461 TM5 Van der Waals
bosentan W336 6.48x48 TM6 Van der Waals
bosentan W336 6.48x48 TM6 aromatic (edge-to-face)
bosentan L339 6.51x51 TM6 hydrophobic
bosentan L339 6.51x51 TM6 Van der Waals
bosentan H340 6.52x52 TM6 Van der Waals
bosentan R343 6.55x55 TM6 polar (charge-assisted hydrogen bond)
bosentan I372 7.39x38 TM7 hydrophobic
bosentan I372 7.39x38 TM7 Van der Waals
bosentan A375 7.42x41 TM7 Van der Waals

Ligands

bosentan

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x56 2.57x56 D154
TM3
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
5x461 5.46x461 Y281
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x52 6.52x52 H340
6x55 6.55x55 R343
TM7
7x38 7.39x38 I372
7x41 7.42x41 A375