PDB
5XPR
Resolution
3.6 Å
Released
Aug. 16, 2017
Receptor
ETB
Class
A
Species
Homo sapiens
Ligand
Function
bosentan
Antagonist
Reference
10.1038/NSMB.3450

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
bosentan H150 2.53x53 TM2 Van der Waals
bosentan D154 2.57x56 TM2 Van der Waals
bosentan N158 2.61x60 TM2 Van der Waals
bosentan V177 3.28x28 TM3 Van der Waals
bosentan P178 3.29x29 TM3 hydrophobic
bosentan Q181 3.32x32 TM3 polar (hydrogen bond)
bosentan K182 3.33x33 TM3 polar (charge-charge)
bosentan V185 3.36x36 TM3 Van der Waals
bosentan F240 4.64x65 TM4 Van der Waals
bosentan C255 45.50x50 ECL2 Van der Waals
bosentan K273 5.38x39 TM5 polar (hydrogen bond)
bosentan L277 5.42x43 TM5 hydrophobic
bosentan Y281 5.46x461 TM5 Van der Waals
bosentan W336 6.48x48 TM6 aromatic (edge-to-face)
bosentan L339 6.51x51 TM6 hydrophobic
bosentan H340 6.52x52 TM6 Van der Waals
bosentan R343 6.55x55 TM6 polar (charge-charge)
bosentan R343 6.55x55 TM6 polar (hydrogen bond)
bosentan I372 7.39x38 TM7 hydrophobic
bosentan A375 7.42x41 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K C M R ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
Helix box plot — Download: PNG | SVG S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7

GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x53 2.53x53 H150
2x56 2.57x56 D154
2x60 2.61x60 N158
TM3
3x28 3.28x28 V177
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
TM4
4x65 4.64x65 F240
ECL2
45x50 45.50x50 C255
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
5x461 5.46x461 Y281
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x52 6.52x52 H340
6x55 6.55x55 R343
TM7
7x38 7.39x38 I372
7x41 7.42x41 A375