Biased Signaling Atlas

dobutamine

Agent/drug
Bioactivity

dobutamine

SMILES	CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1
InChIKey	JRWZLRBJNMZMFE-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	7
Molecular weight (Da)	301.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.35	7.35	7.35	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.73	6.73	6.73	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.25	7.25	7.25	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.87	5.87	5.87	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.20	5.35	5.50	Guide to Pharmacology
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.95	5.95	5.95	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.98	5.98	5.98	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.77	5.77	5.77	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.24	8.24	8.24	Drug Central

Showing 1 to 12 of 12 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.96	6.96	6.96	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.16	8.16	8.16	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.47	6.47	6.47	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.94	6.94	6.94	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.53	5.53	5.53	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pEC50	6.80	6.80	6.80	Guide to Pharmacology
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	5.71	5.71	5.71	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pEC50	8.26	8.26	8.26	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.82	5.82	5.82	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pEC50	8.21	8.21	8.21	Drug Central
D₃	DRD3	Human	Dopamine	A	pIC50	5.30	5.30	5.30	ChEMBL

Showing 1 to 11 of 11 entries

dobutamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 20

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.596	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C01C	0.593	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury of lung, unspecified	NB32.3Z	C01C	0.297	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	C01C	0.074	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis with septic shock	1G41	C01C	0.590	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Shock, unspecified	MG40.Z	C01C	0.573	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.591	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C01C	0.593	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury of lung, unspecified	NB32.3Z	C01C	0.297	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	C01C	0.074	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis with septic shock	1G41	C01C	0.590	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Shock, unspecified	MG40.Z	C01C	0.573	2	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.634	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C01C	0.593	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury of lung, unspecified	NB32.3Z	C01C	0.297	2	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	C01C	0.074	2	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Sepsis with septic shock	1G41	C01C	0.590	2	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Shock, unspecified	MG40.Z	C01C	0.573	2	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.698	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z	C01C	0.607	4	Yes

Showing 1 to 20 of 30 entries

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dobutamine

dobutamine

Chemical Properties

Database connections

Bioactivities

dobutamine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information