PDB
6OS0
Resolution
2.9 Å
Released
Feb. 19, 2020
Receptor
AT1
Class
A
Species
Homo sapiens
Ligand
Function
angiotensin II (Human)
Agonist
Reference
10.1126/SCIENCE.AAY9813

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Ligand Amino Acid Generic Number Segment Interaction Type
angiotensin II (Human) I14 N-term Van der Waals
angiotensin II (Human) Q15 N-term Van der Waals
angiotensin II (Human) D16 N-term Van der Waals
angiotensin II (Human) D17 N-term polar (hydrogen bond with backbone)
angiotensin II (Human) D17 N-term polar (hydrogen bond)
angiotensin II (Human) D17 N-term polar (charge-charge)
angiotensin II (Human) R23 N-term Van der Waals
angiotensin II (Human) Y35 1.39x39 TM1 Van der Waals
angiotensin II (Human) W84 2.60x60 TM2 hydrophobic
angiotensin II (Human) Y87 2.63x63 TM2 Van der Waals
angiotensin II (Human) Y92 ECL1 hydrophobic
angiotensin II (Human) S105 3.29x29 TM3 Van der Waals
angiotensin II (Human) V108 3.32x32 TM3 hydrophobic
angiotensin II (Human) S109 3.33x33 TM3 Van der Waals
angiotensin II (Human) L112 3.36x36 TM3 hydrophobic
angiotensin II (Human) Y113 3.37x37 TM3 hydrophobic
angiotensin II (Human) R167 ECL2 polar (hydrogen bond)
angiotensin II (Human) V179 ECL2 hydrophobic
angiotensin II (Human) A181 45.51x51 ECL2 hydrophobic
angiotensin II (Human) F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
angiotensin II (Human) F182 45.52x52 ECL2 hydrophobic
angiotensin II (Human) H183 ECL2 Van der Waals
angiotensin II (Human) Y184 ECL2 hydrophobic
angiotensin II (Human) Y184 ECL2 polar (hydrogen bond with backbone)
angiotensin II (Human) E185 ECL2 Van der Waals
angiotensin II (Human) S186 ECL2 Van der Waals
angiotensin II (Human) K199 5.42x43 TM5 polar (hydrogen bond)
angiotensin II (Human) K199 5.42x43 TM5 polar (charge-charge)
angiotensin II (Human) K199 5.42x43 TM5 aromatic (pi-cation)
angiotensin II (Human) K199 5.42x43 TM5 hydrophobic
angiotensin II (Human) H1256 6.51x51 TM6 Van der Waals
angiotensin II (Human) D1263 6.58x58 TM6 polar (charge-charge)
angiotensin II (Human) D1263 6.58x58 TM6 polar (hydrogen bond)
angiotensin II (Human) I1266 6.61x61 TM6 Van der Waals
angiotensin II (Human) Q1267 6.62x62 TM6 Van der Waals
angiotensin II (Human) A1277 7.28x27 TM7 Van der Waals
angiotensin II (Human) V1280 7.31x30 TM7 Van der Waals
angiotensin II (Human) D1281 7.32x31 TM7 polar (hydrogen bond)
angiotensin II (Human) D1281 7.32x31 TM7 polar (charge-charge)
angiotensin II (Human) M1284 7.35x34 TM7 hydrophobic
angiotensin II (Human) P1285 7.36x35 TM7 Van der Waals
angiotensin II (Human) I1288 7.39x38 TM7 Van der Waals

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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
Helix box plot — Download: PNG | SVG S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7

GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM1
1x39 1.39x39 Y35
TM2
2x60 2.60x60 W84
2x63 2.63x63 Y87
TM3
3x29 3.29x29 S105
3x32 3.32x32 V108
3x33 3.33x33 S109
3x36 3.36x36 L112
3x37 3.37x37 Y113
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM6
6x51 6.51x51 H256
6x58 6.58x58 D263
6x61 6.61x61 I266
6x62 6.62x62 Q267
TM7
7x27 7.28x27 A277
7x30 7.31x30 V280
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288