PDB
6OS0
Resolution
2.9 Å
Released
Feb. 19, 2020
Receptor
AT1
Class
A
Species
Homo sapiens
Ligand
angiotensin II (Human)
Function
Agonist
Reference
10.1126/SCIENCE.AAY9813

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Ligand Amino Acid Generic Number Segment Interaction Type
angiotensin II (Human) Q15 N-term polar (hydrogen bond with backbone)
angiotensin II (Human) Q15 N-term Van der Waals
angiotensin II (Human) D16 N-term Van der Waals
angiotensin II (Human) D17 N-term polar (charge-assisted hydrogen bond)
angiotensin II (Human) D17 N-term polar (hydrogen bond with backbone)
angiotensin II (Human) R23 N-term Van der Waals
angiotensin II (Human) W84 2.60x60 TM2 Van der Waals
angiotensin II (Human) W84 2.60x60 TM2 hydrophobic
angiotensin II (Human) Y87 2.63x63 TM2 Van der Waals
angiotensin II (Human) Y92 ECL1 hydrophobic
angiotensin II (Human) Y92 ECL1 Van der Waals
angiotensin II (Human) S109 3.33x33 TM3 Van der Waals
angiotensin II (Human) L112 3.36x36 TM3 hydrophobic
angiotensin II (Human) Y113 3.37x37 TM3 hydrophobic
angiotensin II (Human) Y113 3.37x37 TM3 Van der Waals
angiotensin II (Human) R167 ECL2 polar (charge-assisted hydrogen bond)
angiotensin II (Human) V179 ECL2 hydrophobic
angiotensin II (Human) V179 ECL2 Van der Waals
angiotensin II (Human) A181 45.51x51 ECL2 hydrophobic
angiotensin II (Human) A181 45.51x51 ECL2 Van der Waals
angiotensin II (Human) F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
angiotensin II (Human) F182 45.52x52 ECL2 Van der Waals
angiotensin II (Human) H183 ECL2 Van der Waals
angiotensin II (Human) Y184 ECL2 polar (hydrogen bond with backbone)
angiotensin II (Human) Y184 ECL2 Van der Waals
angiotensin II (Human) E185 ECL2 Van der Waals
angiotensin II (Human) K199 5.42x43 TM5 polar (charge-assisted hydrogen bond)
angiotensin II (Human) D1263 6.58x58 TM6 polar (charge-assisted hydrogen bond)
angiotensin II (Human) D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
angiotensin II (Human) M1284 7.35x34 TM7 Van der Waals
angiotensin II (Human) M1284 7.35x34 TM7 hydrophobic
angiotensin II (Human) P1285 7.36x35 TM7 Van der Waals
angiotensin II (Human) I1288 7.39x38 TM7 Van der Waals
angiotensin II (Human) I1288 7.39x38 TM7 hydrophobic

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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
Helix box plot — Download: PNG | SVG S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7

GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM2
2x60 2.60x60 W84
2x63 2.63x63 Y87
TM3
3x33 3.33x33 S109
3x36 3.36x36 L112
3x37 3.37x37 Y113
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM6
6x58 6.58x58 D263
TM7
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288