PDB
7EJX
Resolution
2.4 Å
Released
April 13, 2022
Receptor
GPR88
Class
A
Species
Homo sapiens
Ligand
compound 2 [PMID: 24793972]
Function
Allosteric agonist
Reference
10.1038/S41467-022-30081-5

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Ligand Amino Acid Generic Number Segment Interaction Type
compound 2 [PMID: 24793972] L213 5.59x59 TM5 hydrophobic
compound 2 [PMID: 24793972] I215 5.61x61 TM5 hydrophobic
compound 2 [PMID: 24793972] V216 5.62x62 TM5 hydrophobic
compound 2 [PMID: 24793972] V219 5.65x65 TM5 hydrophobic
compound 2 [PMID: 24793972] S282 ICL3 Van der Waals
compound 2 [PMID: 24793972] S282 ICL3 polar (hydrogen bond with backbone)
compound 2 [PMID: 24793972] G283 6.34x34 TM6 Van der Waals
compound 2 [PMID: 24793972] L284 6.35x35 TM6 Van der Waals
compound 2 [PMID: 24793972] L284 6.35x35 TM6 hydrophobic
compound 2 [PMID: 24793972] V286 6.37x37 TM6 hydrophobic
compound 2 [PMID: 24793972] V286 6.37x37 TM6 Van der Waals
compound 2 [PMID: 24793972] L287 6.38x38 TM6 hydrophobic
compound 2 [PMID: 24793972] L287 6.38x38 TM6 Van der Waals
compound 2 [PMID: 24793972] C290 6.41x41 TM6 Van der Waals
compound 2 [PMID: 24793972] C290 6.41x41 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R K L Q ICL1ECL1 T G S A E P P A D W ECL1ICL2 P A A T Y Q A L Y ICL2ECL2 P P W A P R P G A A P P ECL2ICL3 L N F H L L H Q L P G C A A A A A A F P G A Q H A P G P G G A A H P A Q A Q P L P P A L H P R R A Q R R L S ICL3ECL3 L P V ECL3N-term M T N S S S T S T S S T T G G S L L L L C E N-termC-term G V G D A A A A A V A A T A V P A V S Q A Q L G T R A A G Q H W C-term E E E S W A G R R I P V S L L Y S G L A I G G T L A N G M V I Y L V S S F T T S N A F I V N G C A A D L S V C A L W M P Q E A V L G L L P D G A G G S Y R L L R G G L L G L G L T V S L L S H C L V A L N R Y L L I T R Q R R H T A G M L A L S W A L A L G L V L L L R V H Y P A L L A A A A L L A Q T A L L L H C Y L G I V R R V R V S V K R V S V G L S V L L L C C V F L L A T Q P L V W V S L A S G F S P W G V Q A A S W L L C C A L S A L N P L L Y T W N E E V R S F R R S V L P
Helix box plot — Download: PNG | SVG G N A L T G G I A L G S Y L L S V P I R 1 V N G C A A D L S V C L A W M P Q E A V L 2 L C H S L L S V T L G L G L L G G R L L 3 T A G M L A L S W A L A L G L V L L L 4 Y C H L L L A T Q A L L A A A A L L A P Y 5 L L L C C V F L L A T Q P L V W V S L A 6 L P N L A S L A C C L L W S A A Q V G 7

GPCRdb(A)
GPCRdb(A)
GPR88
TM5
5x59 5.59x59 L213
5x61 5.61x61 I215
5x62 5.62x62 V216
5x65 5.65x65 V219
TM6
6x34 6.34x34 G283
6x35 6.35x35 L284
6x37 6.37x37 V286
6x38 6.38x38 L287
6x41 6.41x41 C290