PDB
7YAC
Resolution
3.2 Å
Released
April 19, 2023
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
Function
paltusotine
Agonist
Reference
10.1038/S41467-023-36673-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
paltusotine Y50 1.39x39 TM1 Van der Waals
paltusotine L99 2.60x60 TM2 hydrophobic
paltusotine Q102 2.63x63 TM2 hydrophobic
paltusotine V103 2.64x64 TM2 Van der Waals
paltusotine M119 3.29x29 TM3 Van der Waals
paltusotine D122 3.32x32 TM3 polar (charge-charge)
paltusotine D122 3.32x32 TM3 polar (hydrogen bond)
paltusotine Q126 3.36x36 TM3 polar (hydrogen bond)
paltusotine F127 3.37x37 TM3 Van der Waals
paltusotine C193 45.50x50 ECL2 Van der Waals
paltusotine T194 45.51x51 ECL2 Van der Waals
paltusotine I195 45.52x52 ECL2 hydrophobic
paltusotine I209 5.39x40 TM5 hydrophobic
paltusotine T212 5.42x43 TM5 hydrophobic
paltusotine F272 6.51x51 TM6 hydrophobic
paltusotine F272 6.51x51 TM6 aromatic (edge-to-face)
paltusotine F294 7.35x34 TM7 hydrophobic
paltusotine V298 7.39x38 TM7 Van der Waals
paltusotine Y302 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM1
1x39 1.39x39 Y50
TM2
2x60 2.60x60 L99
2x63 2.63x63 Q102
2x64 2.64x64 V103
TM3
3x29 3.29x29 M119
3x32 3.32x32 D122
3x36 3.36x36 Q126
3x37 3.37x37 F127
ECL2
45x50 45.50x50 C193
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x40 5.39x40 I209
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
TM7
7x34 7.35x34 F294
7x38 7.39x38 V298
7x42 7.43x42 Y302