SST2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7YAC

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-023-36673-Z

PUBLICATION DATE

April 19, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

33 interactions (Click to see)

LIGANDS

PALTUSOTINE - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 152 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 152 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 S 238 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 238 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 148 34x51 G.H5 F 336 G.H5.08
Polar TM6 K 246 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 246 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM2 T 78 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 148 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 I 148 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 K 234 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 234 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 V 242 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 V 242 - G.H5 D 337 G.H5.09
Hydrophobic TM3 A 143 3x53 G.H5 C 351 G.H5.23
Polar TM3 A 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 156 - G.HN E 28 G.HN.52
Ionic ICL2 R 155 - G.H5 D 350 G.H5.22
Polar ICL2 R 155 - G.H5 D 350 G.H5.22
Hydrophobic TM5 I 231 5x61 G.H5 L 348 G.H5.20
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 231 5x61 G.H5 L 353 G.H5.25
Van-der-waals ICL2 I 148 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 K 253 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 144 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 235 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 235 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 V 242 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 242 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 K 246 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 S 316 8x47 G.H5 G 352 G.H5.24
Polar ICL3 S 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 244 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 244 - G.h4s6 E 318 G.h4s6.12