PDB
8JD6
Resolution
3.4 Å
Released
June 21, 2023
Receptor
mGlu4
Class
C
Species
Homo sapiens
Ligands
L-serine-O-phosphate
VU0364770
Function
Agonist
PAM
Reference
10.1038/S41422-023-00830-2
L-serine-O-phosphate VU0364770

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Ligand Amino Acid Generic Number Segment Interaction Type
L-serine-O-phosphate S159 N-term Van der Waals
L-serine-O-phosphate S159 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate S159 N-term polar (hydrogen bond)
L-serine-O-phosphate A180 N-term Van der Waals
L-serine-O-phosphate A180 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate S181 N-term Van der Waals
L-serine-O-phosphate T182 N-term Van der Waals
L-serine-O-phosphate Y230 N-term hydrophobic
L-serine-O-phosphate Y230 N-term Van der Waals
L-serine-O-phosphate D312 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate D312 N-term Van der Waals
L-serine-O-phosphate S313 N-term Van der Waals
L-serine-O-phosphate S313 N-term polar (hydrogen bond with backbone)
L-serine-O-phosphate K405 N-term polar (charge-assisted hydrogen bond)
VU0364770 I796 6.48x48 TM6 hydrophobic
VU0364770 I796 6.48x48 TM6 Van der Waals
VU0364770 L799 6.51x51 TM6 Van der Waals
VU0364770 L799 6.51x51 TM6 polar (hydrogen bond with backbone)
VU0364770 A800 6.52x52 TM6 Van der Waals
VU0364770 A800 6.52x52 TM6 hydrophobic
VU0364770 I802 6.54x54 TM6 hydrophobic
VU0364770 I802 6.54x54 TM6 Van der Waals
VU0364770 P803 6.55x55 TM6 Van der Waals
VU0364770 P803 6.55x55 TM6 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 T N D P I V K A S ICL1ECL1 A E P ECL1ICL2 V S A P R F I ICL2ECL2 P S H S V V D F Q D Q R T L D P R F A R G V L K C D I ECL2ICL3 R G V P E T F N E ICL3ECL3 A D ECL3N-term M P G K R G L G W W W A R L P L C L L L S L Y G P W M P S S L G K P K G H P H M N S I R I D G D I T L G G L F P V H G R G S E G K P C G E L K K E K G I H R L E A M L F A L D R I N N D P D L L P N I T L G A R I L D T C S R D T H A L E Q S L T F V Q A L I E K D G T E V R C G S G G P P I I T K P E R V V G V I G A S G S S V S I M V A N I L R L F K I P Q I S Y A S T A P D L S D N S R Y D F F S R V V P S D T Y Q A Q A M V D I V R A L K W N Y V S T V A S E G S Y G E S G V E A F I Q K S R E D G G V C I A Q S V K I P R E P K A G E F D K I I R R L L E T S N A R A V I I F A N E D D I R R V L E A A R R A N Q T G H F F W M G S D S W G S K I A P V L H L E E V A E G A V T I L P K R M S V R G F D R Y F S S R T L D N N R R N I W F A E F W E D N F H C K L S R H A L K K G S H V K K C T N R E R I G Q D S A Y E Q E G K V Q F V I D A V Y A M G H A L H A M H R D L C P G R V G L C P R M D P V D G T Q L L K Y I R N V N F S G I A G N P V T F N E N G D A P G R Y D I Y Q Y Q L R N D S A E Y K V I G S W T D H L H L R I E R M H W P G S G Q Q L P R S I C S L P C Q P G E R K K T V K G M P C C W H C E P C T G Y Q Y Q V D R Y T C K T C P Y D M R P T E N R T G C R P I P I I K L E W G S N-termC-term K A V V T A A T M S N K F T Q K G N F R P N G E A K S E L C E N L E A P A L A T K Q T Y V T Y T N H A I C-term P W A V L P L F L A V V G I A A T L F V V I T F V R Y G R E L S Y V L L A G I F L C Y A T T F L M I D L G T C S L R R I F L G L G M S I S Y A A L L T K T N R I Y R I F E Q G K R S S P A S Q L A I T F S L I S L Q L L G I C V W F V V D S D L S L I C L L G Y S M L L M V T C T V Y A I K T A K P I G F T M Y T T C I V W L A F I P I F F G T S Q S K L Y I Q T T T L T V S V S L S A S V S L G M L Y M P K V Y I I L F H P E Q R K R N V P K S L
Helix box plot — Download: PNG | SVG L T A A I G V V A L F L P L V A W P 1 Y V L L A G I F L C Y A T T F L M I 2 T L L A A Y S I S M G L G L F I R R L S 3 Q L A I T F S L I S L Q L L G I C V W F 4 A Y V T C T V M L L M S Y G L L C I L S 5 G F T M Y T T C I V W L A F I P I F F G 6 G L S V S A S L S V S V T L T T T Q I Y 7

GPCRdb(A)
GPCRdb(C)
mGlu4 receptor
TM6
6x46 6.48x48 I796
6x49 6.51x51 L799
6x50 6.52x52 A800
6x52 6.54x54 I802
6x53 6.55x55 P803