mGlu4 receptor - Gi3

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JD6

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41422-023-00830-2

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

43 interactions (Click to see)

LIGANDS

L-serine-O-phosphate - Agonist pubchem gtoplig chembl_ligand drugbank drug_central ,

VU0364770 - PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

L-serine-O-phosphate, L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 S 687 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 S 687 - G.H5 I 343 G.H5.15
Hydrophobic ICL1 K 619 12x51 G.H5 G 352 G.H5.24
Van-der-waals ICL1 K 619 12x51 G.H5 G 352 G.H5.24
Hydrophobic ICL3 F 781 - G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 680 3x57 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 680 3x57 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 694 - G.H5 N 347 G.H5.19
Hydrophobic TM2 R 623 2x36 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 623 2x36 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 680 3x57 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 680 3x57 G.H5 I 344 G.H5.16
Hydrophobic ICL2 S 687 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 S 687 - G.hns1 K 32 G.hns1.03
Polar ICL2 I 694 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 694 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 694 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 688 - G.S1 V 34 G.S1.02
Hydrophobic ICL1 K 619 12x51 G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 619 12x51 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 680 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 680 3x57 G.H5 L 348 G.H5.20
Polar ICL2 V 688 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 688 - G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL3 F 781 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 781 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 686 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 686 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 G 684 - G.H5 T 340 G.H5.12
Hydrophobic TM3 I 680 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 680 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 G 684 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 G 684 - G.H5 I 343 G.H5.15
Hydrophobic TM3 F 681 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 F 681 3x58 G.H5 L 348 G.H5.20
Polar TM4 S 695 4x28 G.H5 C 351 G.H5.23
Hydrophobic TM4 S 695 4x28 G.H5 C 351 G.H5.23
Van-der-waals TM4 S 695 4x28 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 686 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 R 686 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 K 685 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 S 689 - G.hns1 A 31 G.hns1.02
Hydrophobic TM2 G 622 2x35 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 688 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 688 - G.H5 I 343 G.H5.15
Hydrophobic TM4 P 696 4x29 G.H5 C 351 G.H5.23
Van-der-waals TM4 P 696 4x29 G.H5 C 351 G.H5.23
Van-der-waals TM2 E 624 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 677 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 677 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 F 681 3x58 G.H5 I 344 G.H5.16
Van-der-waals TM3 F 681 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL1 K 619 12x51 G.H5 Y 354 G.H5.26
Van-der-waals ICL1 K 619 12x51 G.H5 Y 354 G.H5.26
Hydrophobic TM3 R 676 3x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 G 684 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 G 684 - G.H5 I 344 G.H5.16
Polar ICL1 A 620 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 A 620 12x52 G.H5 L 353 G.H5.25