PDB
8PM2
Resolution
2.9 Å
Released
Aug. 9, 2023
Receptor
TAAR7F
Class
A
Species
Mus musculus
Ligand
N,N-dimethylcyclohexanamine
Function
Agonist
Reference
10.1101/2023.07.07.547762

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Ligand Amino Acid Generic Number Segment Interaction Type
N,N-dimethylcyclohexanamine D127 3.32x32 TM3 polar (charge-assisted hydrogen bond)
N,N-dimethylcyclohexanamine V128 3.33x33 TM3 hydrophobic
N,N-dimethylcyclohexanamine C131 3.36x36 TM3 Van der Waals
N,N-dimethylcyclohexanamine Y132 3.37x37 TM3 hydrophobic
N,N-dimethylcyclohexanamine Y132 3.37x37 TM3 Van der Waals
N,N-dimethylcyclohexanamine N217 5.43x44 TM5 Van der Waals
N,N-dimethylcyclohexanamine W286 6.48x48 TM6 Van der Waals
N,N-dimethylcyclohexanamine W286 6.48x48 TM6 hydrophobic
N,N-dimethylcyclohexanamine Y289 6.51x51 TM6 hydrophobic
N,N-dimethylcyclohexanamine Y289 6.51x51 TM6 Van der Waals
N,N-dimethylcyclohexanamine V312 7.39x38 TM7 hydrophobic
N,N-dimethylcyclohexanamine V312 7.39x38 TM7 Van der Waals
N,N-dimethylcyclohexanamine V315 7.42x41 TM7 hydrophobic
N,N-dimethylcyclohexanamine V315 7.42x41 TM7 Van der Waals
N,N-dimethylcyclohexanamine Y316 7.43x42 TM7 Van der Waals
N,N-dimethylcyclohexanamine Y316 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R Q L H ICL1ECL1 C W Y F ECL1ICL2 P L A Y P T R F ICL2ECL2 A S E A G L E D L V S S L T C V G G C Q I A V ECL2ICL3 R A S D S Y ICL3ECL3 G F I T ECL3N-term M S I A D E T V S W N Q D S I L S R D L F S A T S A E L C Y E N L N R S C V R N-termC-term G K I L R E N S S T T N L F S E C-term S P Y S P G P R L I L Y A V F G F G A V L A V C G N L L V M T S I L H F S P A N F L V A S L A C A D F L V G V M V M P F S M V R S V E G G D S Y C K L H T C F D V S F C Y C S L F H L C F I S V D R Y I A V S D T A S V S G K C I T F S W L L S I S Y G F S L I Y T G N Q T W V F I N F S V F L I P T L V M I T V Y S K I F L I A K Q Q A Q N I E K M S K Q T A K D R V A K R E R K A A K T L G I A V A A F L L S W L P Y F I D S F I D A F L P T Y V Y E I L V W I V Y Y N S A M N P L I Y A F F Y P W I K L F R K A T V T
Helix box plot — Download: PNG | SVG L N G C V A L V A G F G F V A Y L I L R 1 A S L A C A D F L V G M V V M P F S M V R 2 F C L H F L S C Y C F S V D F C T H L K 3 S G K C I T F S W L L S I S Y G F S L I 4 Y V T I M V L T P I L F V S F N I F V W T 5 G I A V A A F L L S W L P Y F I D S F I 6 L P N M A S N Y Y V I W V L I E Y V Y 7

GPCRdb(A)
GPCRdb(A)
TAAR7F
TM3
3x32 3.32x32 D127
3x33 3.33x33 V128
3x36 3.36x36 C131
3x37 3.37x37 Y132
TM5
5x44 5.43x44 N217
TM6
6x48 6.48x48 W286
6x51 6.51x51 Y289
TM7
7x38 7.39x38 V312
7x41 7.42x41 V315
7x42 7.43x42 Y316