TAAR7F - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8PM2

RESOLUTION

2.9 Å

REFERENCE

10.1101/2023.07.07.547762

PUBLICATION DATE

Aug. 9, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

28 interactions (Click to see)

LIGANDS

N,N-dimethylcyclohexanamine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 153 - G.S3 V 217 G.S3.01
Hydrophobic TM6 A 271 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 271 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 249 5x75 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 V 149 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 149 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 T 274 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 274 6x36 G.H5 L 393 G.H5.25
Polar H8 W 332 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 W 332 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 W 332 8x49 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 153 - G.S3 F 219 G.S3.03
Hydrophobic H8 Y 330 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 153 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 153 - G.H5 F 376 G.H5.08
Aromatic TM3 R 145 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 145 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 152 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 152 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 152 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 152 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 152 - G.H5 H 387 G.H5.19
Hydrophobic TM5 A 239 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 249 5x75 G.S6 C 359 G.S6.01
Van-der-waals TM5 M 249 5x75 G.S6 C 359 G.S6.01
Hydrophobic TM5 S 250 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 T 157 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 A 239 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 242 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 153 - G.H5 R 380 G.H5.12
Polar TM5 Q 242 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 242 5x68 G.H5 Q 384 G.H5.16
Ionic TM3 D 151 3x56 G.H5 R 380 G.H5.12
Polar TM3 D 151 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM3 D 151 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM3 V 149 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 155 - G.H5 H 387 G.H5.19
Polar TM3 A 148 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 148 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 148 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 246 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM6 K 270 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 270 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 270 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 275 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 275 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 153 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 153 - G.S1 H 41 G.S1.02
Polar TM5 Q 242 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 242 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 242 5x68 G.H5 D 381 G.H5.13
Polar TM6 T 274 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 274 6x36 G.H5 E 392 G.H5.24
Ionic TM6 K 270 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 270 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 270 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 270 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 148 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 148 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 235 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 235 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 238 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 246 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 246 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 A 239 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 238 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 242 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 249 5x75 G.S6 Y 360 G.S6.02
Hydrophobic ICL2 L 153 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 153 - G.H5 I 383 G.H5.15
Hydrophobic TM5 A 243 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 267 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 V 149 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 149 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 153 - G.H5 C 379 G.H5.11