PDB
8YFS
Resolution
2.8 Å
Released
March 5, 2025
Receptor
MRGPRE
Class
A
Species
Equus asinus
Ligand
(E)-3-(2-methoxyphenyl)prop-2-enal
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
(E)-3-(2-methoxyphenyl)prop-2-enal F100 2.53x53 TM2 hydrophobic
(E)-3-(2-methoxyphenyl)prop-2-enal S131 3.35x35 TM3 polar (hydrogen bond)
(E)-3-(2-methoxyphenyl)prop-2-enal S131 3.35x35 TM3 Van der Waals
(E)-3-(2-methoxyphenyl)prop-2-enal Y132 3.36x36 TM3 polar (hydrogen bond)
(E)-3-(2-methoxyphenyl)prop-2-enal Y132 3.36x36 TM3 Van der Waals
(E)-3-(2-methoxyphenyl)prop-2-enal G256 6.54x54 TM6 Van der Waals
(E)-3-(2-methoxyphenyl)prop-2-enal N283 7.45x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R ICL1ECL1 N R S ECL1ICL2 P I W Y R C R R ICL2ECL2 H F V D ECL2ICL3 R R Q ICL3ECL3 P S L P Y F ECL3N-term M S H E G N A T E S D P T L P L C I L V D G A H A F S A Y N-termC-term L Q S A L T E D V E L S T E E P P S P D D T C-term E N A L F L A I V L L S L C G L V G N G T V I W L L G F R I N P F S V Y I L N L A G A D F A F L F C K S V R F L L F L L V A V L N V L I R G V T F S S Y L G G L S L L M A V S V E R C L S V L F P A Q L S A I A C A L I W G L S L C P G I L V F L C V F S C D V V N L V Y Y G M F F L T F L V L C A S S L V L F I R V Q C F S M P A R L S R I V L L T V L A F L V L G L P L G A G L L T D R L S D I L L P I L H L L S A L N S G V N P L I Y F F M G R Q G Q K V R Q Q R P L R E
Helix box plot — Download: PNG | SVG G N G V L G C L S L L V I A L F L A N E 1 L N L A G A D F A F L F C K S V R F L L 2 A M L L S L G G L Y S S F T V G R I L V 3 S A I A C A L I W G L S L C P G I L V F 4 V L S S A C L V L F T L F F M G Y Y V L 5 L L T V L A F L V L G L P L G A G L L T 6 L P N V G S N L A S L L H L I P L L I 7

GPCRdb(A)
GPCRdb(A)
MRGPRE
TM2
2x53 2.53x53 F78
TM3
3x35 3.35x35 S109
3x36 3.36x36 Y110
TM6
6x54 6.54x54 G234
TM7
7x45 7.45x45 N261