MRGPRE - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Equus asinus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Mus musculus

PDB CODE

8YFS

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

March 5, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

15 interactions (Click to see)

LIGANDS

(E)-3-(2-methoxyphenyl)prop-2-enal - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 W 222 5x62 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 K 345 G.H5.12
Hydrophobic C-term R 296 - G.H5 N 357 G.H5.24
Van-der-waals C-term R 296 - G.H5 N 357 G.H5.24
Polar TM3 R 146 3x50 G.H5 N 357 G.H5.24
Aromatic TM2 F 86 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 F 86 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 F 86 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM6 V 239 6x37 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 239 6x37 G.H5 V 359 G.H5.26
Polar TM3 S 149 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 I 154 34x51 G.S1 L 34 G.S1.02
Hydrophobic TM3 V 150 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 353 G.H5.20
Polar ICL2 R 157 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 157 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 150 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 C 158 34x55 G.S1 L 34 G.S1.02
Hydrophobic TM5 W 222 5x62 G.H5 L 353 G.H5.20
Hydrophobic TM2 N 84 2x37 G.H5 Y 356 G.H5.23
Van-der-waals TM2 N 84 2x37 G.H5 Y 356 G.H5.23
Aromatic ICL2 Y 156 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 156 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 156 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL3 F 226 - G.H5 Q 350 G.H5.17
Hydrophobic ICL3 F 226 - G.H5 L 349 G.H5.16
Hydrophobic TM3 R 146 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 146 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 C 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 219 5x59 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 I 154 34x51 G.H5 K 345 G.H5.12
Polar ICL2 P 153 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 153 34x50 G.H5 N 352 G.H5.19
Polar ICL2 C 158 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 C 158 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 C 158 34x55 G.hns1 R 31 G.hns1.02
Ionic ICL2 R 157 34x54 G.H5 E 355 G.H5.22
Polar ICL2 R 157 34x54 G.H5 E 355 G.H5.22
Hydrophobic ICL2 I 154 34x51 G.S3 V 192 G.S3.01
Van-der-waals ICL2 I 154 34x51 G.S3 V 192 G.S3.01
Polar ICL2 R 157 34x54 G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 157 34x54 G.H5 N 352 G.H5.19
Polar ICL2 R 157 34x54 G.H5 M 351 G.H5.18
Hydrophobic ICL2 R 157 34x54 G.H5 M 351 G.H5.18
Van-der-waals ICL2 R 157 34x54 G.H5 M 351 G.H5.18
Hydrophobic TM2 P 85 2x38 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 85 2x38 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 157 34x54 G.H5 I 348 G.H5.15
Van-der-waals ICL2 R 157 34x54 G.H5 I 348 G.H5.15
Hydrophobic TM2 F 86 2x39 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 154 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 I 154 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM6 V 239 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 239 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 L 349 G.H5.16
Polar ICL2 R 160 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 160 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 160 34x57 G.hns1 R 31 G.hns1.02