Structure information

GIP receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8YW4

SPECIES

Homo sapiens

RESOLUTION

3.260

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00700-0

PUBLICATION DATE

Sept. 18, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Retatrutide L35 N-term hydrophobic
Retatrutide F127 1.29x29 TM1 hydrophobic
Retatrutide L134 1.36x36 TM1 hydrophobic
Retatrutide L137 1.39x39 TM1 hydrophobic
Retatrutide Q138 1.40x40 TM1 Van der Waals
Retatrutide Q138 1.40x40 TM1 polar (hydrogen bond)
Retatrutide Y141 1.43x43 TM1 Van der Waals
Retatrutide Y141 1.43x43 TM1 hydrophobic
Retatrutide Y145 1.47x47 TM1 polar (hydrogen bond)
Retatrutide I187 2.64x64 TM2 Van der Waals
Retatrutide I187 2.64x64 TM2 hydrophobic
Retatrutide R190 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Retatrutide R196 ECL1 polar (charge-assisted hydrogen bond)
Retatrutide Q224 3.37x37 TM3 polar (hydrogen bond)
Retatrutide Q224 3.37x37 TM3 Van der Waals
Retatrutide V227 3.40x40 TM3 Van der Waals
Retatrutide V227 3.40x40 TM3 hydrophobic
Retatrutide E288 45.52x52 ECL2 polar (hydrogen bond with backbone)
Retatrutide E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Retatrutide R289 ECL2 polar (charge-assisted hydrogen bond)
Retatrutide N290 ECL2 polar (hydrogen bond with backbone)
Retatrutide N290 ECL2 Van der Waals
Retatrutide W296 5.36x37 TM5 Van der Waals
Retatrutide W296 5.36x37 TM5 hydrophobic
Retatrutide R300 5.40x40 TM5 Van der Waals
Retatrutide L374 7.39x38 TM7 hydrophobic
Retatrutide E377 7.42x41 TM7 Van der Waals
Retatrutide I378 7.43x42 TM7 Van der Waals
Retatrutide I378 7.43x42 TM7 hydrophobic

Ligands

Retatrutide

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Residue Diagrams

L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7
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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x25 1.29x29 F127
1x32 1.36x36 L134
1x35 1.39x39 L137
1x36 1.40x40 Q138
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x57 2.64x64 I187
2x60 2.67x67 R190
TM3
3x33 3.37x37 Q224
3x36 3.40x40 V227
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
5x44 5.40x40 R300
TM7
7x34 7.39x38 L374
7x37 7.42x41 E377
7x38 7.43x42 I378